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首页> 外文期刊>Indian journal of physiology and pharmacology >Effect of Laboratory Stressor on Arterial Compliance in Young Women
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Effect of Laboratory Stressor on Arterial Compliance in Young Women

机译：实验室压力源对年轻女性动脉遵从的影响

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Introduction: Coronary Heart Disease (CHD) is lower in women in comparison to male which is attributed to the effect of estrogen on vascular system. However, report on estrogen replacement therapy in menopausal women on blood pressure reactivity is inconsistent. The psychosocial stressors of daily life trigger elevated sympathetic response which is an important independent cardiovascular risk factor. Therefore, the present study intends to determine the effect of laboratory stressor on arterial compliance in young women during different phases of menstrual cycle. Methods: It is a cross-sectional, observational study conducted on 24 students of 18-22 years of age group. The participants attended two sessions in late follicular (days 12-15) and luteal phase (days 21-24). The anthropometric parameters and detailed menstrual history were recorded. They were exposed to a 5-min Mental Arithmetic Stress Test (MAST). Peripheral SBP, DBP, central SBP, DBP, Heart rate (HR), Augmentation Index, and brachial ankle pulse wave velocity (baPWV) were recorded before and during the test. Paired t test was performed to compare the means of the parameters and linear regression analysis was done to examine the association between cardiovascular parameters and MAST score in both phases. ANCOVA was done to examine the difference in MAST response between follicular and luteal phases. Results: BMI and WHR of the subjects were mostly within normal limits with few exceptions. Heart rate was significantly decreased during MAST in follicular phase. However, baPWV was increased significantly during MAST in both phases. There was an increasing trend in other parameters during MAST in both phases excepting pulse pressure. No association between cardiovascular parameters and MAST score was revealed by linear regression analysis. There was no significant difference in MAST score in both phases. Conclusions: An increasing trend of cardiovascular parameters during MAST was observed because of elevated sympathetic activity. A decrease in HR was observed in certain participants during both phases while performing MAST. This decline in peripheral vascular response may enhance the risk of major cardiovascular events in future. This study therefore concludes that the effect of laboratory stressor in the form of Mental Arithmetic Stress Test (MAST) superimposed on the effect of ovarian hormones, decreases arterial compliance as measured indirectly by baPWV.
机译：介绍：与男性相比，女性冠心病（CHD）较低，归因于雌激素对血管系统的影响。但是，关于血压反应性的绝经妇女雌激素替代治疗的报告是不一致的。日常生活的心理社会压力源引发升高的交感神经反应，这是一个重要的独立心血管危险因素。因此，本研究旨在确定实验室压力源对月经周期不同阶段的少妇动脉依从性的影响。方法：是在18-22岁的24名年龄段进行的24名学生进行的横断面观察研究。参与者参加了晚毛囊（第12-15天）和肺阶段的两次会议（第21-24天）。记录了人类测量参数和详细的月经历史。它们暴露于5分钟的精神算术应激测试（桅杆）。在测试之前和期间，在测试中记录了外围SBP，DBP，中央SBP，DBP，心率（HR），增强指数和臂踝脉搏波速度（BAPWV）。进行配对的T检验以比较参数的装置，并进行线性回归分析，以检查心血管参数和两个阶段的桅杆得分之间的关​​联。 Ancova是为了检查卵泡和肺阶段之间的桅杆响应差异。结果：受试者的BMI和WHR大多数在正常限制范围内，少数例外。在卵泡阶段桅杆期间心率显着下降。然而，在两个阶段的桅杆期间，BAPWV显着增加。在除脉冲压力的两个阶段，桅杆期间其他参数呈其他参数呈增加。线性回归分析揭示了心血管参数和桅杆分数之间的关联。两个阶段的桅杆得分没有显着差异。结论：由于交感神经活动提高，观察了桅杆期间心血管参数的越来越趋势。在执行桅杆的同时，在两个阶段的某些参与者中观察到HR的减少。这种外周血管反应的下降可能会在未来提高主要心血管事件的风险。因此，本研究得出结论，实验室压力源以叠加在卵巢激素的效果上的精神算术应激试验（桅杆）的影响，降低了通过BAPWV间接测量的动脉顺应性。

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