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首页> 外文期刊>Indian journal of physiology and pharmacology >Effect of Ascorbic Acid on Interleukin-2 Secretion By T Lymphocytes In Whole Blood Cultures
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Effect of Ascorbic Acid on Interleukin-2 Secretion By T Lymphocytes In Whole Blood Cultures

机译：抗坏血酸对全血培养中T淋巴细胞的白细胞介素-2分泌的影响

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The effect of vitamin C on T lymphocyte function is not clear. In-vivo supplementation of vitamin C is found to have a stimulatory effect on T cells while studies in which ascorbic acid was added to T cell cultures show an inhibition of cell function. The study aims to investigate the effect of ascorbic acid on interleukin-2 secretion by T cells in whole blood cultures which better resembles the physiological environment than pure T cell cultures. It was found that ascorbic acid, when added to whole blood cultures at a very high concentration of 1 mM, inhibits interleukin-2 secretion by T cells (p<0.05). However at lower concentrations of 0.25 mM and 0.5 mM significant inhibition was not seen which is contrary to earlier reports in pure T cell cultures. Hence it can be concluded that ascorbic acid inhibits T cell function in-vitro at high concentrations but the effect is relatively less in whole blood cultures compared to pure T cell cultures.
机译：维生素C对T淋巴细胞功能的影响尚不清楚。 发现维生素C的体内补充对T细胞具有刺激作用，同时向T细胞培养物中加入抗坏血酸的研究显示细胞功能。 该研究旨在探讨抗坏血酸对整个血液培养物中T细胞的白细胞介素-2分泌的影响，这比纯T细胞培养物更好地类似于生理环境。 发现抗坏血酸，当以非常高浓度的1mm添加到全血培养时，抑制T细胞的白细胞介素-2分泌（P <0.05）。 然而，在较低浓度的0.25mm和0.5mm的显着抑制下，没有看到与纯T细胞培养物中的早期报道相反。 因此可以得出结论，抗坏血酸在高浓度下抑制在体外体外函数，但与纯T细胞培养物相比，整个血液培养物中的效果相对较低。

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