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首页> 外文期刊>Indian journal of physiology and pharmacology >Effect of Load on In-situ Rat Skeletal Muscle Preparation Under Free Loaded and After Loaded Condition
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Effect of Load on In-situ Rat Skeletal Muscle Preparation Under Free Loaded and After Loaded Condition

机译：载荷对原位大鼠骨骼肌制剂在自由加载和加载后的情况下

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摘要

Purpose of the study: The effect of free loaded and after loaded condition in mammalian skeletal muscle contraction can be studied using an in-situ nerve-muscle preparation in rat. The experimental setup mimics the physiological conditions very closely unlike the classical in vitro frog nerve-muscle preparation and hence could be considered as an effective practical module to demonstrate the work done in a skeletal muscle in both free loaded and after loaded condition. Methodology: A simple, feasible and novel practical is designed in which muscle twitch is recorded in an in-situ nerve-muscle preparation of an anaesthetized rat under free loaded and after loaded condition at different weights using an isotonic transducer. Work done was calculated under free loaded and after loaded condition and compared. Main finding: Difference was observed with respect to displacement and work done during free loaded and after loaded condition. Work done was higher in free loaded condition. Conclusion: We propose a simple and novel practical to demonstrate the effect of free loaded and after loaded condition in muscle twitch for undergraduate teaching in physiology.
机译：该研究的目的：使用大鼠原位神经肌肉制剂，可以研究哺乳动物骨骼肌收缩中的自由载荷和负载条件的影响。实验设置模仿生理条件非常密切地不同于古典体外青蛙神经肌肉制备，因此可以被认为是一种有效的实际模块，以证明在骨骼肌中的骨骼肌中的工作中完成的工作。方法论：设计简单，可行和新颖的实用，其中肌肉抽搐在使用等渗传感器的不同重量的自由加载和加载条件下的无麻醉大鼠的原位神经肌肉制备中记录。完成的工作是在加载条件下的自由加载和后处理的。主要发现：在自由加载和加载条件下，在置换和工作中观察到差异。在免费加载条件下完成的工作更高。结论：我们提出了一种简单简洁的实用性，证明了在肌肉抽搐中为生理学中的本科教学中的肌肉抽搐造成的自由载和载荷的病情。

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