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首页> 外文期刊>Indian journal of physiology and pharmacology >Evaluation Of Antidepressant Activity Of Statins Alone And In Combination With Fluoxetine In Acute And Chronic Behavioural Models Of Depression
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Evaluation Of Antidepressant Activity Of Statins Alone And In Combination With Fluoxetine In Acute And Chronic Behavioural Models Of Depression

机译：单独评价他汀类药物的抗抑郁活性及氟西汀在急性和慢性行为模型中的抑制作用

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Context: To study the role of statins (Atorvastatin, Simvastatin, and Pravastatin) as novel pharmacological option in treatment of depression. Aim: To evaluate antidepressant activity of statins (HMG-CoA reductase inhibitor) in combination with Fluoxetine in acute and chronic forced swim test in rats. Design: An experimental animal study. Materials and methods : Male albino wistar rats of either sex with weight range 150-250 grams were used. Part 1 is Dose finding study in acute forced swim test with three doses of Atorvastatin (2.5 mg/kg, 5 mg/ kg, 10 mg/kg), Simvastatin (2.5 mg/kg, 5 mg/kg, 10 mg/kg), and Pravastatin (10 mg/kg, 20 mg/kg, 40 mg/ kg) each were done. Part 2 was conducted to study the effects of statins (Atorvastatin, Simvastatin, and Pravastatin) and Fluoxetine (10 mg/kg) per se and in combination, on immobility of rats in acute forced swim test were compared. In part 3 effects of statins (Atorvastatin, Simvastatin, and Pravastatin) and Fluoxetine per se and in combination on immobility of rats in chronic forced swim test were compared. Open field test was performed to discriminate between the general behavioural stimulation (false positives) and antidepressant effect of study drugs. All study drugs were given orally. In Part 2 & 3 maximum effective dose of statin from part 1 was utilised. Statistics: ANOVA with post-hoc Tukeys test, significant effects were analyzed further using post hoc Newman-Keuls tests. Results: In part 1 of dose finding study most effective doses for Atorvastatin, Simvastatin and Pravastatin were 10 mg/kg, 10 mg/kg and 40 mg/kg respectively. In this part acute forced swim test showed, no statistically significant reduction in duration of immobility by any of the statins (Atorvastatin, Simvastatin, and Pravastatin) as compared to control. In Part 2 acute forced swim test, When combined with Fluoxetine, Atorvastatin (157.83 ± 10.51) and Simvastatin (167.66 ± 7.71) showed significant reduction in duration of
机译：背景：研究他汀类药物（阿托伐他汀，辛伐他汀和普伐他汀）作为一种治疗抑郁症的新药理学选择。目的：评估他汀类药物（HMG-COA还原酶抑制剂）与大鼠急性和慢性强制游泳试验中的氟西汀组合的抗抑郁活性。设计：实验动物研究。材料和方法：使用重量范围150-250克的雄性白化Wistar大鼠150-250克。第1部分是急性强制游泳试验中的剂量发现研究，具有三剂阿托伐他汀（2.5mg / kg，5mg / kg，10 mg / kg），辛伐他汀（2.5 mg / kg，5 mg / kg，10 mg / kg） ，并进行普伐他汀（10mg / kg，20mg / kg，40mg / kg）。第2部分进行研究，以研究他汀类药物（阿托伐他汀，辛伐他汀和普伐他汀）和氟西汀（10mg / kg）本身并组合的影响，对比较急性强制游泳试验中的大鼠的不动。在第3次（阿托伐他汀，辛伐他汀和普伐他汀）和氟西汀本身的影响和氟西汀和组合对慢性强制游泳试验大鼠的不动。进行开场测试以区分一般行为刺激（假阳性）和研究药物的抗抑郁效应。所有研究药物都是口头给出的。在第2部分和3部分中，利用来自第1部分的最大有效剂量。统计数据：具有后HOC Tukeys测试的ANOVA，使用HOC Newman-Keuls测试进一步分析了显着的影响。结果：在剂量发现的第1部分中，分别为10mg / kg，10mg / kg和40mg / kg的多伐他汀。在该部分急性强制游泳试验中显示出，与对照相比，任何他汀类药物（阿托伐他汀，辛伐他汀和普伐他汀）没有统计学上显着降低。在第2部分中，当与氟西汀联合时，阿托伐他汀（157.83±10.51）和辛伐他汀（167.66±7.71）的持续时间显着降低

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