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首页> 外文期刊>Indian journal of physiology and pharmacology >Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats
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Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats

机译：阿贝尔马丘斯骨折（秋葵）种子提取物在果糖诱导的高血压大鼠抗高血压作用

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摘要

The aim of this study was to investigate the protective activity of ethanolic Abelmoschus esculentus seed extract (EAESE) in fructose-induced Hypertensive rat model. Even though several synthetic drugs have been discovered to treat hypertension, it is important to observe the contribution of the daily diet in easing the hypertension and hence the possible therapeutic activity of the seeds from the fruit was studied. The rats were divided randomly into 4 groups (n=6). Group I was considered as the Normal control. Group II animals were treated with only 10% w/v Fructose solution for 6 weeks (42 days). Group III animals were treated with 10% w/v Fructose solution for 6 weeks (42 days) and EAESE (150 mg/kg bw p.o) after 3 weeks i.e. from the 22nd day till the end of the study period (42nd day). Group IV animals were treated with 10% w/v Fructose solution for 6 weeks (42 days) and Enalapril (10 mg/kg bw p.o) after 3 weeks i.e. from the 22nd day till the end of the study period (42nd day). Physiological parameters ECG, heart rate and blood pressure were measured and recorded by the invasive method and the Serum parameters: Total Cholesterol and Triglyceride were measured. Result: The ECG pattern and Heart rate was improved in the EAESE treated Hypertensive rats. Remarkable reduction in the Blood pressure [systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP)] levels were observed along with a significant reduction in the Total cholesterol and Triglyceride levels. Conclusion: From the results obtained, it can be suggested that the ethanolic extract of Abelmoschus esculentus seeds has the potential antihypertensive activity as well anti-hyperlipidaemic activity.
机译：本研究的目的是探讨果糖诱导的高血压大鼠模型中乙醇亚贝尔科血症种子提取物（EAESE）的保护活性。尽管已经发现几种合成药物治疗高血压，但重要的是观察日常饮食在缓解高血压中的贡献，因此研究了种子来自水果的可能治疗活性。将大鼠随机分成4组（n = 6）。群体被认为是正常控制。 II组动物的果糖溶液仅为6周（42天）。在3周后，用10％w / v果糖溶液用10％w / v果糖溶液治疗，在3周后（150mg / kg p.o）处理，从第22天（第42天）至第22天（第42天）。将IV组动物用10％w / v果糖溶液治疗6周（42天）和3周后的烯丙醇（10mg / kg bw p.o），在第22天至第22天至研究期间（第42天）。通过侵入方法和血清参数测量和记录生理参数ECG，心率和血压：测量总胆固醇和甘油三酯。结果：EAESE治疗的高血压大鼠ECG模式和心率得到改善。血压显着降低[收缩动脉压（SAP），舒张动动脉压（DAP）和平均动脉压（MAP）]水平随着总胆固醇和甘油三酯水平的显着降低。结论：从所得结果中，可以提出阿伯莫斯科骨骼种子的乙醇提取物具有抗高脂活性的潜在抗高血脂活性。

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