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首页> 外文期刊>Indian journal of physiology and pharmacology >COMPARATIVE STUDY OF PULMONARY FUNCTIONS AND OXIDATIVE STRESS IN SMOKERS AND NON-SMOKERS.
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COMPARATIVE STUDY OF PULMONARY FUNCTIONS AND OXIDATIVE STRESS IN SMOKERS AND NON-SMOKERS.

机译：吸烟者和非吸烟者肺功能和氧化应激的比较研究。

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Abstract : Chronic Obstructive Pulmonary Disorder (COPD) is projected to rank third leading cause of deaths by 2030 as per WHO. COPD is a multi-etiological disease. The airflow dysfunction is usually progressive, associated with an abnormal inflammatory response of tKe lungs to noxious particles or gasses. As the lung is exposed to high levels of oxygen, it is more susceptible to oxidants mediated injury. Gender based differences are identifiable risk factors. Smoking is found to be a major risk factor in the causation of COPD resulting in oxidative stress . The aim of the present study is to evaluate the oxidant antioxidant imbalance in healthy non smoker controls and smokers with COPD. A total of 60 control (healthy non smokers) and 121 smokers having COPD were studied. The mean age is more in smoker group as compared to healthy controls, which identifies advancing age as a risk factor for COPD. The mean BMI and weight of smoker group is reduced as compared to control group. GOLD 2008 criteria was used to assess lung functions. Lung functions namely FEV1, FVC, FEV1/FVC% and FEV1% Predicted showed significant reduction in smoker group as compared to healthy non smoker controls. MDA in control and smoker group (1.09+0.09 and 1.41+0.23 nmol/ml respectively) showed significant changes (P<0.001). Our results also demonstrate significant reduction in anti oxidant enzymes namely SOD (units/mg of serum protein), Catalase (units/mg of serum protein) and GPX (nmol of NADPH oxidized/ min/mg of serum protein) in smoker group as compared to healthy controls. On the basis of study it is concluded that smoking, gender and oxidant antioxidant imbalance are identifiable risk factors in COPD.
机译：摘要：预计慢性阻塞性肺部障碍（COPD）将按2030年排列第三次导致死因。 COPD是一种多病因疾病。气流功能障碍通常是进行的，与TKE肺的异常炎症反应相关，对有氧颗粒或气体。随着肺部暴露于高水平的氧气，它更容易受到氧化剂介导的损伤。基于性别的差异是可识别的风险因素。发现吸烟是COPD导致导致氧化应激的主要风险因素。本研究的目的是评估健康的非吸烟者对照和吸烟者的氧化剂抗氧化不平衡。研究了60例对照（健康的非吸烟者）和121名吸烟者进行了研究。与健康对照相比，吸烟者的平均年龄更多，将年龄识别为COPD的危险因素。与对照组相比，吸烟组的平均BMI和重量减少。黄金2008标准用于评估肺功能。肺功能即FEV1，FVC，FEV1 / FVC％和FEV1％预测显示，与健康的非吸烟者控制相比，吸烟者的显着减少了。控制和吸烟组中的MDA（分别为1.09±0.09和1.41 + 0.23 nmol / ml）显示出显着的变化（P <0.001）。我们的研究结果还表明，抗氧化剂酶的显着降低即SOD（单位/ mg蛋白），在吸烟者组中的SOD（单位/ mg蛋白），过氧化氢酶（单位/ mg蛋白）和GPX（Nmol NADPH氧化/ min / mg蛋白蛋白）相比相比健康的控制。在研究的基础上，得出的结论是，吸烟，性别和氧化剂抗氧化不平衡是COPD中可识别的危险因素。

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