Glutamate Transporter Inhibitor Advances the Ischemia-induced Depression of Spinal Synaptic Transmission in Rats in vitro

Amar N. Maurya; Anil K. Tiwari; Archana Jha; Shripad B. Deshpe

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Glutamate Transporter Inhibitor Advances the Ischemia-induced Depression of Spinal Synaptic Transmission in Rats in vitro

机译：谷氨酸转运蛋白抑制剂在体外大鼠脊柱突触传递的血液突触速度抑制前进

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Ischemia depresses the spinal la-a motoneuron synaptic transmission via NMDA dependent mechanism. We postulated that glutamate transporter inhibitor (DL-threo-β-hydroxy aspartate, THA) advances the ischemia-induced depression. The experiments were performed on isolated, hemisected spinal cord from 4-6 day old rats. The stimulation of a dorsal root (L_(35)) with supramaximal strength at 0.1 Hz elicited monosynaptic (MSR) and polysynaptic reflex (PSR) potentials in the corresponding segmental ventral root. Superfusion of ischemic solution (glucose free without O_2 bubbling) depressed the spinal reflexes in a time-dependent manner and abolished them within 50 min. THA alone did not alter the magnitude of MSR and PSR up to 20 min while THA+ischemia abolished the reflexes within 25 min. The abolition time was significantly advanced in THA+ischemia group as compared to ischemia only group. The results indicate that glutamate transporter inhibitor advances the ischemia-induced depression of spinal reflexes substantiating glutamatergic action at this synapse.

机译：缺血通过NMDA依赖机构抑制脊髓LA-A Motoneuron突触传递。我们假设谷氨酸转运蛋白抑制剂（DL-Threo-β-羟基天冬氨酸，THA）推进缺血诱导的抑郁症。从4-6天的老鼠孤立的半殖脊髓进行实验。在相应的节条件根部的0.1Hz引发的单颌骨（MSR）和多腹反射（PSR）电位下，刺激背根（L_（35））的刺激（L_（35））。缺血溶液的叠加（没有O_2鼓泡的葡萄糖）以时间依赖性方式抑制脊柱反射并在50分钟内取消了它们。单独的Tha没有改变MSR和PSR的大小，最多20分钟，而Tha +缺血在25分钟内取消了反应。与缺血群体相比，在+缺血组中，在血液缺血组中取消时间显着提出。结果表明，谷氨酸转运蛋白抑制剂促进血液反射的缺血诱导的抑制在该突触在该突触处的谷氨酸胶作用。

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《Indian journal of physiology and pharmacology》 |2016年第4期|共6页
作者
Amar N. Maurya; Anil K. Tiwari; Archana Jha; Shripad B. Deshpe;
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Department of Physiology Institute of Medical Sciences Banaras Hindu University Varanasi;

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正文语种 eng
中图分类人体生理学;
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1. Glutamate Transporter Inhibitor Advances the Ischemia-induced Depression of Spinal Synaptic Transmission in Rats in vitro [J] . Amar N. Maurya, Anil K. Tiwari, Archana Jha, Indian journal of physiology and pharmacology . 2016,第4期

机译：谷氨酸转运蛋白抑制剂在体外大鼠脊柱突触传递的血液突触速度抑制前进
2. Deprenyl blocks the aglycemia-induced depression of the synaptic transmission but not the ischemia-induced depression in neonatal rat spinal cord in vitro. [J] . Jha A, Das Gupta S, Deshpande SB Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2003,第1期

机译：异戊二烯在体外能抑制新生鼠脊髓中的无糖血症引起的突触传递抑制，但不会引起缺血引起的抑制。
3. Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn. [J] . Galik J, Youn DH, Kolaj M, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第4期

机译：第一组代谢型谷氨酸受体和谷氨酸转运蛋白参与脊髓背角中缓慢的兴奋性突触传递。
4. DURATION OF NERVE ROOT COMPRESSIVE TRAUMA MODULATES THE SUBSEQUENT THERMAL HYPERALGESIA SPINAL EXPRESSION OF THE GLUTAMATE TRANSPORTER, GLT1 [C] . Kristen J. Nicholson, Taylor M. Gilliland, Beth A. Winkelstein ASME bioengineering conference . 2014

机译：神经根压迫性创伤的持续时间可调节继发性热痛觉过敏和谷氨酸转运蛋白GLT1的脊髓表达
5. Part one. Synthesis of phosphorus-containing amino acid analogues derived from trans-4-hydroxyproline and the study of their bioactivity in the glutamate excitatory neurotransmitter system. Part two. Synthesis, structural modifications and in vitro pharmacology of quinoline-2,4-dicarboxylic acids as proposed inhibitors of the glutamate vesicular transporter. [D] . Carrigan, Christina Nicole. 2000

机译：第一部分。反式-4-羟基脯氨酸衍生的含磷氨基酸类似物的合成及其在谷氨酸兴奋性神经递质系统中的生物活性的研究。第二部分。喹啉-2,4-二羧酸作为谷氨酸囊泡转运蛋白的抑制剂的合成，结构修饰和体外药理作用。
6. Depression of NMDA receptor-mediated synaptic transmission by four α2 adrenoceptor agonists on the in vitro rat spinal cord preparation [O] . E S L Faber, J P Chambers, R H Evans 1998

机译：四种α2肾上腺素受体激动剂对离体大鼠脊髓制剂的NMDA受体介导的突触传递的抑制作用
7. Depression of NMDA receptor-mediated synaptic transmission by four α2 adrenoceptor agonists on the in vitro rat spinal cord preparation [O] . Faber, E S L, Chambers, J P, Evans, R H 1998

机译：四种α2肾上腺素受体激动剂对离体大鼠脊髓制剂的NMDA受体介导的突触传递的抑制作用

Glutamate Transporter Inhibitor Advances the Ischemia-induced Depression of Spinal Synaptic Transmission in Rats in vitro

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