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首页> 外文期刊>Indian journal of physiology and pharmacology >Prophylactic Choline Supplementation Attenuates Vascular Cognitive Impairment in Rodent Model of Ischemic Stroke
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Prophylactic Choline Supplementation Attenuates Vascular Cognitive Impairment in Rodent Model of Ischemic Stroke

机译：预防性胆碱补充衰减缺血性卒中啮齿动物模型中的血管认知障碍

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Introduction: Stroke is the second leading cause of mortality in the world and estimated to be about 0.22% in India. Current management of post stroke vascular cognitive impairment (VCI) is not satisfactory. Choline is an important component of neuronal membrane phospholipids known to enhance cognition. Objective: To explore the prophylactic efficacy of choline in attenuating VCI in a rat model of ischemic brain injury. Materials and Methods: 10 month old male Wistar rats (n=8/group) were assigned as normal control, Bilateral common carotid artery occlusion (BCCAO), Sham BCCAO and Prophylactic BCCAO choline supplemented groups. Subsequently, all the groups of rats were subjected to cognitive function tests. Results: BCCAO rats showed significant deficits (p< 0.05) in cognitive functions compared to age matched sham BCCAO and NC rats. Prophylactic supplementation of choline in chronic cerebral hypoperfusion ischemic brain injured rats significantly restored learning and memory abilities (P<0.001) compared to age matched BCCAO rats. Conclusion: Prophylactic dietary choline supplementation attenuates vascular cognitive impairment in rodent model of ischemic stroke. Thus, after appropriate human clinical trials, dietary choline supplementation may be considered as a preventive strategy to attenuate post stroke cognitive impairment in high risk individuals.
机译：介绍：中风是世界死亡率的第二个主要原因，估计印度约为0.22％。后冲程血管认知障碍（VCI）的目前管理并不令人满意。胆碱是众所周知的神经元膜磷脂的重要组成部分，以增强认知。目的：探讨胆碱在缺血性脑损伤大鼠大鼠模型中衰减VCI的预防疗效。材料和方法：10个月大的雄性Wistar大鼠（n = 8 /组）被分配为正常对照，双侧常见的颈动脉闭塞（Bccao），假冒Bccao和预防性Bccao Choline补充组。随后，对所有大鼠组进行认知函数测试。结果：与年龄匹配的假冒BCCAO和NC大鼠相比，BCCAO大鼠在认知函数中表现出显着的缺陷（P <0.05）。慢性脑低渗缺血性脑内胆碱的预防补充大鼠的血液受损大鼠的学习和记忆能力（P <0.001）与年龄匹配的BCCAO大鼠相比。结论：预防性膳食胆碱补充剂在缺血性卒中啮齿动物模型中衰减血管认知障碍。因此，在适当的人体临床试验后，膳食胆碱补充剂可被视为预防策略，以减轻高危人员患者后卒中后认知障碍的策略。

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