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首页> 外文期刊>Annals of clinical psychiatry: official journal of the American Academy of Clinical Psychiatrists >Systematic review of benzodiazepines for anxiety disorders in late life
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Systematic review of benzodiazepines for anxiety disorders in late life

机译：苯并二氮卓在后期生命中焦虑症的系统评价

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background: Benzodiazepines are currently the most commonly prescribed medication for the treatment of anxiety in older adults, although there is a dearth of good-quality data on this subject. The aim of this review was to systematically review studies examining the efficacy and tolerability of benzodiazepines for the treatment of anxiety disorders among older adults. methods: The authors conducted a systematic review, searching PubMed, Ovid MEDLINE, Ovid Embase, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. All searches were limited to English-language articles. The quality of each study was appraised using criteria developed by the Centre for Evidence-Based Medicine for randomized controlled trials. results: A total of 8,785 citations were retrieved and pooled in EndNote and de-duplicated to 3,753. This set was uploaded to Covidence for screening. Two separate screeners (AG and SAP) evaluated the titles, abstracts, and full text of the eligible articles. Five studies met the inclusion criteria. Across all studies, benzodiazepines were associated with decreased anxiety at the end of the study period. The limited tolerability data show mild adverse effects from the benzodiazepines studied. Limitations of the trials included limited data on the long-term use of benzodiazepines for anxiety and a preponderance of trials examining generalized anxiety disorder, with relatively less data on other anxiety disorders. conclusions: Benzodiazepines are effective for treating anxiety disorders in late life, at least in the short term, but more data is needed to establish tolerability and their long-term benefits.
机译：背景：苯并二氮卓目前是最常见的成本药物治疗老年人焦虑的药物，尽管对这个主题有一种缺乏质量的资质。该审查的目的是系统地审查研究苯二氮卓类药物治疗老年人焦虑症的疗效和耐受性的研究。方法：作者进行了系统审查，搜索PubMed，Ovid Medline，Ovid Embase，Science Web，系统性评论的Cochrane数据库和控制试验的Cochrane中央登记。所有搜索都仅限于英语文章。每项研究的质量使用由循证医学中心开发的用于随机对照试验的标准进行评估。结果：在尾注8,785引文中，以终点和重复汇集到3,753。该集合上传到Covidence进行筛选。两个单独的筛选器（AG和SAP）评估了符合条件的文章的标题，摘要和全文。五项研究符合纳入标准。在所有研究中，苯并二氮卓在研究期结束时与焦虑降低有关。有限的可耐受性数据显示来自研究的苯并二氮卓的温和不利影响。试验的局限性包括关于苯二氮卓类药物的有限数据，用于焦虑和审查广泛性焦虑症的试验的优势，对其他焦虑症的数据相对较少。结论：苯二氮卓类药物对于治疗后期焦虑症有效，至少在短期内，但需要更多的数据来建立可宽容性及其长期效益。

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