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首页> 外文期刊>Advances in Chemical Science >A New Spectrophotometric Method for the Simultaneous Multicomponent Analysis Resolution of Cefixime and Dicloxacillin Sodium in Their Tablet Dosage Form
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A New Spectrophotometric Method for the Simultaneous Multicomponent Analysis Resolution of Cefixime and Dicloxacillin Sodium in Their Tablet Dosage Form

机译：分光光度法同时测定头孢克肟和双氯西林钠片剂的多组分含量

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摘要

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical ratio spectra derivative method for the simultaneous determination of Cefixime and Dicloxacillin sodium in tablet dosage form. The method is based on the use of the first derivative of the ratio-spectra obtained by dividing the absorption spectrum of binary mixtures by a standard spectrum of one of the compounds. The cefixime was estimated directly at the 289 nm (A-max of cefixime) without any interference of dicloxacillin sodium. The first derivative amplitudes at 227.2 nm was selected for estimation of dicloxacillin sodium. The wavelength interval (Dl) was selected as 8 nm. Methanol was used as the solvent. Both the drugs showed linearity in the range of 3-16 μg/ml. The method was successfully applied for the determination of these two drugs in tablet dosage form. No interference was observed from excipients present in the tablet. The suitability of this method for the quantitative determination of Cefixime and Dicloxacillin sodium was proved by validation. The proposed method was found to be simple and sensitive for the routine analysis of these two drugs in tablet dosage form. The results of analysis have been validated statistically by recovery studies.
机译：本手稿描述了同时测定片剂剂型中头孢克肟和双氯西林钠的简单，灵敏，快速，准确，精确和经济的比率光谱导数法。该方法基于使用比率光谱的一阶导数，该比率光谱是通过将二元混合物的吸收光谱除以一种化合物的标准光谱获得的。头孢克肟在289 nm（头孢克肟的A-最大值）处直接估计，而没有双氯西林钠的干扰。选择在227.2 nm处的一阶导数振幅来估计双氯西林钠。波长间隔（D1）被选择为8nm。甲醇用作溶剂。两种药物的线性均在3-16μg/ ml的范围内。该方法已成功应用于片剂剂型中这两种药物的测定。片剂中的赋形剂未观察到干扰。通过验证证明了该方法适用于定量测定头孢克肟和双氯西林钠的适用性。对于片剂剂型的这两种药物的常规分析，发现所提出的方法简单而灵敏。分析结果已通过回收率研究进行了统计验证。

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