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首页> 外文期刊>Inhalation toxicology >Behavior-based yield for electronic cigarette users of different strength eliquids based on natural environment topography
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Behavior-based yield for electronic cigarette users of different strength eliquids based on natural environment topography

机译：基于自然环境地形的不同强度灰烬电子烟用品的行为产量

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Introduction: The extent to which electronic cigarette users will compensate for lower nicotine eliquids has Implications on the risk associated with regulating eliquid composition. This article elucidates topography as a compensatory mechanism by investigating the impact of nicotine strength on total particulate matter (TPM) and nicotine consumed per puff. Methods: Thirty-three experienced vape pen users were assigned an NJOY? VapePen and AVAIL? brand Tobacco Row eliquid with their usual nicotine strength (L = 6mg/mL, M = 12mg/mL, H = 18mg/mL) and vaped through RIT's wPUM? vape pen monitor to record every puff during 1 week. Nicotine and TPM yield per puff was determined accounting for the impact of topography characteristics on emissions and used to compute participant-specific mean yield per puff. Results: Nicotine yields ranged from 0.01 to 0.05 mg/puff and varied widely within each group (L, M, and H nicotine strength). Group-wise mean flow rate was lower for L compared to M (p = 0.2) and duration was higher compared to M (p = 0.09). Larger TPM was consumed per puff for L compared to M (p = 0.07), yet nicotine per puff for L was less than M (p = 0.3). H users took smaller volumes than L (p = 0.1) or M (p = 0.17), and there was little difference between L and M (p = 0.47). Conclusions: Evidence was provided for topography as a compensatory mechanism. Use of low nicotine strength eliquids can increase TPM, which can lead to increase in HPHC. Regulatory review of new products should consider natural use topography and realistic use exposures to nicotine, TPM and HPHCs.
机译：介绍：电子卷烟用户将弥补下尼古丁的各种程度对与调节电量组合物相关的风险有影响。本文通过研究尼古丁强度对每次粉扑消耗的总颗粒物（TPM）和尼古丁的影响来阐明形式作为补偿机制。方法：三十三位经验丰富的Vape笔用户被分配了一个njoy？ Vapepen和有用吗？品牌烟草排含有常用的尼古丁强度（L = 6mg / ml，m = 12mg / ml，H = 18mg / ml），并通过rit的wpum蒸发？ Vape Pen Monitor在1周内记录每次泡沫。每次粉扑的尼古丁和TPM产量是确定地形特征对排放的影响，并用于计算每个粉扑的参与者特定的平均产量。结果：尼古丁产量范围为0.01至0.05mg /粉扑，在每组内广泛变化（L，M和H尼古丁强度）。与M（P = 0.2）相比，L较低的组平均流量较低，与M相比，持续时间更高（P = 0.09）。与m相比，每次粉扑消耗较大的TPM（P = 0.07），但每次粉扑的尼古丁小于m（p = 0.3）。 H用户比L（p = 0.1）或m（p = 0.17）取得较小的量，L和M之间几乎没有差异（p = 0.47）。结论：提供了证据作为补偿机制的地形。使用低尼古丁强度灰烬可以增加TPM，这可能导致HPHC增加。对新产品的监管审查应考虑自然使用地形和现实用途暴露于尼古丁，TPM和HPHS。

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