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首页> 外文期刊>BJU international >The rectal administration of lidocaine gel and tolerance of transrectal ultrasonography-guided biopsy of the prostate: a prospective randomized placebo-controlled study.
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The rectal administration of lidocaine gel and tolerance of transrectal ultrasonography-guided biopsy of the prostate: a prospective randomized placebo-controlled study.

机译：利多卡因凝胶的直肠给药和经直肠超声引导的前列腺活检的耐受性：一项前瞻性随机安慰剂对照研究。

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摘要

OBJECTIVE: To evaluate the effect of the rectal administration of lidocaine gel on the tolerance of systematic sextant transrectal ultrasonography (TRUS)-guided prostatic biopsies. PATIENTS AND METHODS: From January to September 1997, patients undergoing initial biopsy mapping of the prostate (with six systematic TRUS-guided transrectal biopsies) were randomized using a pre-established randomization list into two groups. In group 1, 15 mL of 2% lidocaine gel (Astra, Sodertalje, Sweden) was administered intrarectally 15 min before the biopsies. In group 2 (placebo), 15 mL of trans-sonic hydrophilic gel (Rivadis Laboratory, Thouars, France) was administered transrectally under the same conditions. Patients were randomized and the gel administered by a nurse; neither the patients nor the urologists were aware of which product was administered. At the end of the procedure, patients were asked to score the severity of discomfort of the biopsies, using a self-administered rating scale. RESULTS: In all, 109 patients were included, in either group 1 (56 patients) or group 2 (53 patients). Slight pain or no pain was experienced by the vast majority of patients in both groups. Moderate to severe pain was experienced in 12.5% of patients in group 1 and 11.3% of patients in group 2. There was no difference in patient tolerance between the groups (P=0.39). Only minor complications occurred and complication rates were not significantly different between the groups. CONCLUSION: The rectal administration of lidocaine has no impact on the tolerance to prostatic biopsy.
机译：目的：评价利多卡因凝胶直肠给药对系统性六分点经直肠超声（TRUS）引导的前列腺活检的耐受性。患者与方法：从1997年1月至1997年9月，使用预先建立的随机对照表将接受前列腺活检的患者（进行六次系统性TRUS引导的经直肠活检）随机分组。在第1组中，在活检前15分钟直肠内给予15 mL 2％利多卡因凝胶（Astra，Sodertalje，瑞典）。在第2组（安慰剂）中，在相同条件下经直肠给予15 mL的超音速亲水性凝胶（Rivadis Laboratory，Thouars，法国）。将患者随机分组，并由护士给予凝胶;患者和泌尿科医师均不知道使用哪种产品。手术结束时，要求患者使用自我管理的评分量表对活检的不适程度进行评分。结果：第1组（56例）或第2组（53例）总共纳入109例患者。两组中的绝大多数患者都感到轻微疼痛或没有疼痛。第一组的患者中有12.5％发生中度至重度疼痛，而第二组的患者中有11.3％经历了中度至重度疼痛。两组之间的患者耐受性无差异（P = 0.39）。两组之间仅发生轻微并发症，并发症发生率无显着差异。结论：利多卡因的直肠给药对前列腺活检的耐受性没有影响。

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