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首页> 外文期刊>Internal medicine journal >Prevalence of pulmonary arterial hypertension in an Australian scleroderma population: screening allows for earlier diagnosis.
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Prevalence of pulmonary arterial hypertension in an Australian scleroderma population: screening allows for earlier diagnosis.

机译：澳大利亚硬皮病人群中肺动脉高压患病率：筛选允许早期的诊断。

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BACKGROUND: We sought to determine the prevalence of pulmonary complications and especially pulmonary arterial hypertension (PAH) in an Australian scleroderma population. METHODS: Between July 2005 and June 2007, physicians in Western Australia were asked to refer patients with scleroderma specifically for pulmonary hypertension screening. All patients were assessed for PAH and other respiratory conditions using echocardiography, lung function testing and clinical assessments. Right heart catheterization was carried out in patients with evidence of increased right ventricular systolic pressure. RESULTS: Of the 184 patients analysed, 44 had possible PAH on echocardiography. Right heart catheterization confirmed the diagnosis in 24 (13%). Diffuse interstitial lung disease was found in 32 patients representing a point prevalence of 17.4%. The severity of PAH at diagnosis varied according to whether the patients were referred for screening (group A) or for diagnostic (group B) purposes. The 6-min-walk test distance and median pulmonary vascular resistance were significantly worse in group B versus group A (324 vs 402 m; P= 0.02 and 884 dynes/s per cm(-5) vs 486 dynes/s per cm(-5); P < 0.01, respectively). CONCLUSION: Screening may result in earlier diagnosis of PAH with, in general more mild disease. This is important, given that early treatment for PAH while patients are less symptomatic is associated with improved exercise tolerance and pulmonary haemodynamics: indices indicative of disease progression and clinical worsening.
机译：背景：我们试图确定澳大利亚硬皮病人口中肺部并发症和肺动脉高血压（PAH）的患病率。方法：2005年7月至2007年6月，西澳大利亚的医生被要求将患有硬皮病的患者参考肺动脉高压筛查。使用超声心动图，肺功能测试和临床评估评估所有患者的PAH和其他呼吸状况。右心导管插入患者在患者中进行了右心室收缩压增加的患者。结果：184例患者分析，44例在超声心动图中可能进行过PAH。右心导管插入率证实了24例（13％）的诊断。在32例患者中发现弥漫性间质性肺病，其患病点为17.4％。根据患者是否被称为筛选（A组）或用于诊断（B组）目的，PAH在诊断中的严重程度变化。在B组（324 vs 402 m; P = 0.02和884达因/厘米（-5）vs 486达因/ s每cm（ - -5）; P <0.01分别）。结论：筛选可能导致PAH的早期诊断，一般更轻微的疾病。鉴于PAH的早期治疗患者的早期治疗症状，患者较少的症状与改善的运动耐受性和肺血流动力学有关：指示疾病进展和临床恶化的指标。

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