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首页> 外文期刊>International immunopharmacology >Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse
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Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse

机译：叶黄素对乙酰氨基酚诱导的小鼠急性肝衰竭的保护作用

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摘要

Acetaminophen (APAP) is widely used as a safety analgesic and antipyretic agent. Although considered safe at therapeutic doses, overdose of APAP can cause acute liver injury that is sometimes fatal, requiring efficient pharmacological intervention. Luteolin is a naturally occurring flavonoid which is abundant in plants. The objective of this study was to investigate corresponding anti-oxidative and anti-inflammatory activities of luteolin, using acetaminophen-treated mice as a model system. Male C57BL/C mice were randomly divided into three groups (n = 6 each). The control group was given phosphate buffered saline (PBS) orally. The APAP group was given APAP by intraperitoneal injection (i.p) at 300 mg/kg suspended in PBS. The luteolin-treated group was given APAP and luteolin (0-100 mg/kg/day, 1 or 3 days before APAP administration) suspended in PBS orally. 16 h after APAP administration, the liver and serum were collected to determine the liver injury. Luteolin administration significantly decreased acetaminophen-induced serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), malondialdehyde (MDA) levels, as well as glutathione (GSH) depletion and decrease of superoxide dismutase (SOD). Luteolin restored SOD, GSH and GSH-px activities and depressed the expression of pro-inflammatory factors, such as inducible nitric oxide synthase (i-NOS), TNF-alpha, nuclear factor kappa B (NF-kappa B), and IL-6, respectively. Moreover, luteolin down-regulated acetaminophen-induced nitrotyrosine (NT) formation and endoplasmic reticulum (ER) stress. These results suggest the presence of anti-oxidative, anti-inflammatory and anti-ER stress properties of luteolin in response to acetaminophen-induced liver injury in mice. (C) 2015 Published by Elsevier B.V.
机译：乙酰氨基酚（APAP）广泛用作安全镇痛和退热剂。尽管在治疗剂量下被认为是安全的，但过量的APAP会导致有时致命的急性肝损伤，需要有效的药理学干预。叶黄素是一种天然存在的黄酮，其在植物中丰富。本研究的目的是研究使用乙酰胺蛋白处理的小鼠作为模型系统的相应抗氧化和抗炎活性。将雄性C57BL / C小鼠随机分为三组（每个n = 6）。对照组口服磷酸盐缓冲盐水（PBS）。 APAP组通过腹膜内注射（I.P）在PBS中悬浮在300mg / kg。将叶黄素处理的基团进行APAP和叶英蛋白（0-100mg / kg /天，1或3天，前APAP给药前）悬浮在PBS中。 APAP给药后16小时，收集肝脏和血清以确定肝损伤。叶黄素给药显着降低了乙酰氨基酚诱导的血清丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），肿瘤坏死因子α（TNF-α），白细胞介素6（IL-6），丙二醛（MDA）水平以及谷胱甘肽（GSH超氧化物歧化酶（SOD）的耗尽和降低。叶黄素恢复了SOD，GSH和GSH-PX的活动，并抑制了促炎因子的表达，例如诱导型一氧化氮合酶（I-NOS），TNF-α，核因子Kappa B（NF-Kappa B）和IL- 6分别为6。此外，叶黄素下调乙酰氨基酚诱导的硝基荧光蛋白（NT）形成和内质网（ER）应激。这些结果表明，响应于乙酰氨基酚诱导的小鼠肝损伤的抗氧化，抗炎和抗-ER胁迫性能的存在。 （c）2015年由elestvier b.v出版。

著录项

  • 来源
    《International immunopharmacology》 |2015年第1期|共7页
  • 作者

    Tai Minghui; Zhang Jingyao; Song Sidong; Miao RunChen; Liu Sushun; Pang Qing; Wu Qifei; Liu Chang;

  • 作者单位

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

    Xi An Jiao Tong Univ Dept Thorac Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Luteolin; Acetaminophen; Reactive oxygen species; Endoplasmic reticulum stress;

    机译：叶黄素;乙酰氨基酚;反应性氧物种;内质网胁迫;

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