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首页> 外文期刊>International immunopharmacology >Peanut shell extract inhibits the development of dextran sulfate sodium (DSS)-induced colitis
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Peanut shell extract inhibits the development of dextran sulfate sodium (DSS)-induced colitis

机译：花生壳提取物抑制葡聚糖硫酸钠钠（DSS）诱导的结肠炎的发育

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Inflammatory bowel diseases (IBD) induce inflammation in the colon and small intestine. IBD include ulcerative colitis and Crohn's disease, with such common symptoms as severe diarrhea, fever, and blood in the stool. In the current study, we explored the ability of peanut shell extract (PSE) to alleviate IBD in an experimental colonic inflammation model. Colitis was induced by orally administered dextran sulfate sodium (DSS) in mice. Peanut shell extract was prepared using a method of aqueous ethanol. DSS treatment reduced the colon length and mouse body weight, and aggravated disease condition compared with untreated control mice. Oral administration of 400 mg/kg PSE alleviated colon shortening, body weight loss, DAI, and colon injury score in DSS-induced colitis. These physiological improvements were validated by reduced levels of proinflammatory cytokines and infiltrating macrophage accumulation in the inflamed colon in the PSE administered group. These observations suggest that PSE may be developed as an alternative natural extract for the prevention or treatment of IBD.
机译：炎症性肠病（IBD）在结肠和小肠中诱发炎症。 IBD包括溃疡性结肠炎和克罗恩病，具有如此常见的症状，作为严重的腹泻，发热和粪便中的血液。在目前的研究中，我们探讨了花生壳提取物（PSE）在实验结肠炎症模型中缓解IBD的能力。通过口服给予小鼠的葡聚糖硫酸钠（DSS）诱导结肠炎。使用乙醇水溶液制备花生壳提取物。与未处理的对照小鼠相比，DSS治疗降低了结肠长度和小鼠体重，加重疾病病症。 400毫克/千克PSE的口服给药缓解结肠缩短，体重减轻，DAI和结肠损伤和结肠损伤得分在DSS诱导的结肠炎中。通过降低的促炎细胞因子和浸润在PSE施用组中发炎的结肠水平降低的水平验证了这些生理改进。这些观察结果表明，PSE可以作为预防或治疗IBD的替代自然提取物。

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