...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation
【24h】

S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation

机译：S-烯丙基半胱氨酸可防止脂多糖诱导的C57BL / 6小鼠菌株中的急性肾损伤：氧化应激和炎症的参与

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-inflammatory and antioxidant properties. In this research, we tried to determine the protective effect of SAC pretreatment in a mouse model of AKI. To induce AKI, lipopolysaccharide (LPS) was injected once (10 mg/kg, i.p.) and SAC was administered at doses of 25, 50, or 100 mg/kg (p.o.) 1 h before LPS. Treatment of LPS-challenged C56BL/6 animals with SAC lowered serum level of creatinine and blood urea nitrogen (BUN), partially restored renal oxidative stress-related biomarkers including malondialdehyde (MDA), glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase in addition to improvement of mitochondrial membrane potential (MMP). Furthermore, SAC was capable to bring renal nuclear factor-kappaB (NF-kappa B), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), cyclooxygenase-2 (COX2), tumor necrosis factor alpha (TNF alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), Annexin V, and DNA fragmentation partially back to their control levels. Additionally, SAC pretreatment was capable to exert a protective effect, as shown histologically by lower tubular injury and pathologic changes in the kidney. In summary, SAC is capable to alleviate LPS-induced AKI through mitigation of renal oxidative stress, inflammation, and apoptosis in addition to preservation of mitochondrial integrity and its favorable effect exhibits a dose-dependent pattern,
机译：脓毒症是一种严重和生命的危及生命的医疗条件，具有较高的患者发病率和死亡率以及急性肾损伤等并发症（AKI）。 S-烯丙基半胱氨酸（SAC）是药用植物大蒜（Allium Sativum）的活性组成部分，具有多种有益效果，包括抗炎和抗氧化性能。在这项研究中，我们试图确定SAC预处理在AKI小鼠模型中的保护作用。为了诱导AKI，注射脂多糖（LPS）一次（10mg / kg，i.p.）和囊在LPS之前以25,50或100mg / kg（p.O.）1小时的剂量施用。治疗LPS攻击的C56BL / 6动物，具有囊肿的肌酐和血液尿素氮（BUN），部分恢复的肾氧化应激相关生物标志物，包括丙二醛（MDA），谷胱甘肽（GSH）和超氧化物歧化酶的活性（SOD除了改善线粒体膜电位（MMP）之外，还原过氧化氢酶。此外，SAC能够引起肾核因子-κB（NF-Kappa B），核因子（红细胞衍生2） - 麦克风2（NRF2），Toll样受体4（TLR4），环氧氧酶-2（COX2），肿瘤坏死因子α（TNFα），白细胞介素-1β（IL-1β），白细胞介素-6（IL-6），annexin V和DNA碎片部分返回其对照水平。另外，囊预处理能够施加保护效果，如通过较低的管损伤和肾脏病理变化组织学上所示。总之，除了保存线粒体完整性之外，SAC能够通过减轻肾氧化应激，炎症和凋亡，并且其有利效果表现出剂量依赖性图案以及依赖性效果来缓解LPS诱导的AKI。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号