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首页> 外文期刊>International immunopharmacology >Natural killer cells involved in tumour immune escape of hepatocellular carcinomar
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Natural killer cells involved in tumour immune escape of hepatocellular carcinomar

机译：患有肝细胞癌的肿瘤免疫逃逸的天然杀伤细胞

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摘要

Natural killer cells are the first line of host immune surveillance and play major roles in the defence against infection and tumours. Hepatic NK cells exhibit unique phenotypic and functional characteristics compared to Circulating and spleen NK cells, such as higher levels of cytolytic activity and cytotoxicity mediators against tumour cells. However, the activities of NK cells may be reversed during tumour progression. Recent studies demonstrated that hepatic NK cells were exhausted in hepatocellular carcinoma (HCC) and exhibited impaired cytolytic activity and decreased production of effector cytokines. The present review discusses current knowledge on the role of exhausted NK cells in promoting HCC development and the mechanisms contributing to tumour immune escape, including an imbalance of activating and inhibitory receptors on NK cells, abnormal receptor-ligand interaction, and cross-talk with immune cells and other stromal cells in the tumour environment. We provide a fundamental basis for further study of innate immunity in tumour progression and serve the purpose of exploring new HCC treatment strategies.
机译：天然杀手细胞是第一行宿主免疫监测，并在防御感染和肿瘤中发挥重大作用。与循环和脾脏NK细胞相比，肝脏NK细胞表现出独特的表型和功能特性，例如较高水平的细胞溶解活性和针对肿瘤细胞的细胞毒性介质。然而，在肿瘤进展期间，NK细胞的活性可能会逆转。最近的研究表明，肝细胞在肝细胞癌（HCC）中耗尽，并且表现出损伤的细胞溶解活性并降低效应细胞因子的产生。本综述讨论了关于耗尽的NK细胞在促进HCC开发方面的作用的现有知识以及导致肿瘤免疫逃逸的机制，包括对NK细胞的激活和抑制受体的不平衡，异常受体 - 配体相互作用以及与免疫串扰细胞和其他基质细胞在肿瘤环境中。我们为进一步研究肿瘤进展的先天免疫力提供了一个根本的基础，并提供了探索新的HCC治疗策略的目的。

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