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首页> 外文期刊>International immunopharmacology >Intravenous administration of MIP-1alpha with intra-tumor injection of P. acnes shows potent anti-tumor effect.
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Intravenous administration of MIP-1alpha with intra-tumor injection of P. acnes shows potent anti-tumor effect.

机译：静脉内施用MIP-1Alpha，具有肿瘤内注射P. Acnes显示有效的抗肿瘤作用。

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摘要

Dendritic cells (DCs) play a key role as potent biological adjuvants in anti-tumor host responses. However, DC-based vaccination does not always eradicate tumors effectively. Clinical evidence suggests that a strategy to recruit a substantial number of DCs into the tumor mass might provoke proficient anti-tumor immune responses. Here we describe that myeloid DCs (mDCs) efficiently accumulate in tumor sites after intravenous injection of recombinant macrophage inflammatory protein (MIP)-1alpha when pretreated locally with adjuvants like Propionibacterium acnes. Combined treatment of tumor-bearing mice with MIP-1alpha and P. acnes also recruited a large number of natural killer cells (NK cells) to both tumor sites and regional lymph nodes (LNs) and induced a strong T helper 1 immunity at an early time. This early response later led to accumulation of CD8(+) T cells, retraction of tumors and survival of animals treated with P. acnes/MIP-1alpha. In vivo depletion of NK cells or CD8(+) T cells impaired anti-tumor effects, suggesting that activation of NK cells and CD8(+) T cells contributes to anti-tumor immunity in this model. Therefore, this study provides a novel therapeutic strategy for cancer treatment using MIP-1alpha and certain adjuvants.
机译：树突状细胞（DCS）在抗肿瘤宿主反应中发挥关键作用作为有效的生物佐剂。然而，基于DC的疫苗接种并不总是有效地消除肿瘤。临床证据表明，招募大量DCS进入肿瘤肿块的策略可能会引起巨大的抗肿瘤免疫应答。在这里，我们描述了髓样DCs（MDC）在用诸如丙酸杆菌等辅助剂局部预处理的重组巨噬细胞炎症蛋白（MIP）-1Alpha之后有效地积聚在肿瘤部位。用MIP-1Alpha和P.Acnes的携带肿瘤小鼠的结合治疗还招募了大量的天然杀手细胞（NK细胞），肿瘤部位和区域淋巴结（LNS），并在早期诱导强烈的T Herper 1免疫力时间。这种早期反应后来导致CD8（+）T细胞的积累，肿瘤的缩回和用P.Acnes / MIP-1α处理的动物的存活。在体内耗尽NK细胞或CD8（+）T细胞的抗肿瘤作用受损，表明NK细胞和CD8（+）T细胞的激活有助于该模型中的抗肿瘤免疫。因此，本研究为使用MIP-1α和某些佐剂提供了一种用于癌症治疗的新疗法策略。

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