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首页> 外文期刊>International immunopharmacology >Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy
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Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

机译：Celastrol通过自噬的上调来改善IL-10缺陷小鼠的实验性结肠炎

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摘要

Background: Celastrol had been proved effective in the treatment for IBD, probably with the modulation of oxidative stress, inflammatory cytokines and intestinal homeostasis. This study was aimed to investigate whether celastrol could ameliorate the inflammation of IL-10 deficient mice, a murine model of Crohn's disease (CD) with the induction of autophagy.
机译：背景：Celastrol已被证明在IBD的治疗中有效，可能随着氧化应激，炎症细胞因子和肠道稳态的调节。 本研究旨在调查Celastrol是否可以改善IL-10缺陷小鼠的炎症，克罗恩病（CD）的诱导自噬。

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  • 来源
    《International immunopharmacology》 |2015年第1期|共8页
  • 作者

    Zhao Jie; Sun Ye; Shi Peiliang; Dong Jian-Ning; Zuo Lu-Gen; Wang Hong-Gang; Gong Jian-Feng; Li Yi; Gu Li-Li; Li Ning; Li Jie-Shou; Zhu Wei-Ming;

  • 作者单位

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Ctr Diag &

    Treatment Joint Dis Nanjing Drum Tower Hosp Sch Med Nanjing 210002;

    Nanjing Univ Model Anim Res Ctr MOE Key Lab Model Anim Dis Study Nanjing 210002 Jiangsu;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

    Nanjing Univ Jinling Hosp Dept Gen Surg Sch Med Nanjing 210002 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Colitis; Celastrol; Autophagy; Inflammation;

    机译：结肠炎;Celastrol;自噬;炎症;

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