Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

Zhao Jie; Sun Ye; Shi Peiliang; Dong Jian-Ning; Zuo Lu-Gen; Wang Hong-Gang; Gong Jian-Feng; Li Yi; Gu Li-Li; Li Ning; Li Jie-Shou; Zhu Wei-Ming

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Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

机译：Celastrol通过自噬的上调改善了IL-10缺陷小鼠的实验性结肠炎

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Background: Celastrol had been proved effective in the treatment for IBD, probably with the modulation of oxidative stress, inflammatory cytokines and intestinal homeostasis. This study was aimed to investigate whether celastrol could ameliorate the inflammation of IL-10 deficient mice, a murine model of Crohn's disease (CD) with the induction of autophagy.

机译：背景：Celastrol已被证明可有效治疗IBD，可能通过调节氧化应激，炎性细胞因子和肠道稳态来实现。这项研究旨在研究Celastrol是否可以改善IL-10缺陷小鼠的炎症，IL-10缺陷小鼠是克罗恩病（CD）诱导自噬的鼠模型。

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来源
《International immunopharmacology》 |2015年第1期|共8页
作者
Zhao Jie; Sun Ye; Shi Peiliang; Dong Jian-Ning; Zuo Lu-Gen; Wang Hong-Gang; Gong Jian-Feng; Li Yi; Gu Li-Li; Li Ning; Li Jie-Shou; Zhu Wei-Ming;
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正文语种 eng
中图分类药理学;
关键词
Colitis; Celastrol; Autophagy; Inflammation;

机译：结肠炎;鼻咽;自噬;炎症;

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专利

1. Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy [J] . Zhao Jie, Sun Ye, Shi Peiliang, International immunopharmacology . 2015,第1期

机译：Celastrol通过自噬的上调改善了IL-10缺陷小鼠的实验性结肠炎
2. Autophagy induction by rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice [J] . Zhao Jie, Wang Honggang, Yang Haojun, International immunopharmacology . 2020,第1期

机译：雷帕霉素的自噬诱导改善了实验性结肠炎并改善了IL-10敲除小鼠中的肠上皮阻隔功能
3. Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice [J] . Liu Jianhui, Wang Honggang, Li Yi, Biological & pharmaceutical bulletin . 2018,第9期

机译：抗小鼠CD52治疗通过抑制Th1 / 17介导的炎症和促进IL-10缺陷小鼠的Tregs分化来改善结肠炎
4. Melphalan Reduces the Severity of Experimental Colitis in Mice by Blocking Tumor Necrosis Factor-α Signaling Pathway [C] . GALINA SHMARINA, ALEXANDER PUKHALSKY, VLADIMIR ALIOSHKIN, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：美法仑通过阻断肿瘤坏死因子-α信号通路降低小鼠实验性结肠炎的严重性
5. Lack of APC-derived IL-10 contributes to the pathogenesis of colitis in IL-10 deficient mice. [D] . Albright, Carol. 2003

机译：缺乏APC衍生的IL-10会导致IL-10缺陷小鼠结肠炎的发病。
6. GPR120 a potential therapeutic target for experimental colitis in IL-10 deficient mice [O] . Jie Zhao, Honggang Wang, Peiliang Shi, 2017

机译：GPR120IL-10缺陷小鼠实验性结肠炎的潜在治疗靶标
7. Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice [O] . Jianhui Liu, Honggang Wang, Yi Li, 2018

机译：抗小鼠CD52治疗通过抑制Th1 / 17介导的炎症和促进IL-10缺陷小鼠的Tregs分化来改善结肠炎

Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

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