A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption

Maggini Valentina; Lombardi Niccolo; Lenti Maria Carmela; Masi Stefano; Trapani Sandra; Pugi Alessandra; Mugelli Alessandro; Vannacci Alfredo

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A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption

机译：与阿巴丁醇消费相关的儿科史蒂文 - 约翰逊综合征

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We describe a case of Steven-Johnson Syndrome (SJS) associated with albuterol exposure in a 6-year-old male. A possible contributing role of albuterol in SJS occurrence in the present case is strongly suggested by the temporal relationship between the event and the initiation of drug therapy as well as by the positive rechallenge. To the best of our knowledge, albuterol had not been previously associated with SJS in medical literature. It can be therefore possible that physicians, pediatricians in particular, probably not aware of the possible risk of albuterol-induced SJS, might underestimate skin reactions in children taking the drug, thus underreporting this kind of severe adverse drug reaction. (C) 2015 Elsevier B.V. All rights reserved.

机译：我们描述了一个史蒂文-Johnson综合征（SJS）的案例与6岁的男性中的阿巴丁醇暴露有关。通过事件与药物治疗的态度关系以及阳性重新检查的时间关系，强烈建议对本案件中的混合物在本案中发生的可能促进作用。据我们所知，阿巴丁尔以前尚未与医学文献中的SJ相关联。因此，医生尤其可能不了解均无意识到阿巴丁酚诱导的SJ的可能风险，可能会低估服用药物的儿童的皮肤反应，从而在这种严重的不良药物反应中遭到宣布。（c）2015 Elsevier B.v.保留所有权利。

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来源
《International immunopharmacology》 |2015年第1期|共2页
作者
Maggini Valentina; Lombardi Niccolo; Lenti Maria Carmela; Masi Stefano; Trapani Sandra; Pugi Alessandra; Mugelli Alessandro; Vannacci Alfredo;
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作者单位

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

Anna Meyer Childrens Univ Hosp Dept Emergency Med I-50141 Florence Italy;

Anna Meyer Childrens Univ Hosp Dept Pediat I-50141 Florence Italy;

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

Univ Florence Tuscan Reg Ctr Pharmacovigilance Dept Neurosci Psychol Drug Res &

Child Hlth Neuro;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Steven-Johnson Syndrome; Pediatrics; Asthma; Albuterol; Pharmacovigilance; Emergency department;

机译：Steven-Johnson综合征;儿科;哮喘;albuterol;药物理解;急诊部;

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1. A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption [J] . Maggini Valentina, Lombardi Niccolo, Lenti Maria Carmela, International immunopharmacology . 2015,第1期

机译：与阿巴丁醇消费相关的儿科史蒂文 - 约翰逊综合征
2. Population pharmacokinetics of (R)-albuterol and (S)-albuterol in pediatric patients aged 4-11 years with asthma. [J] . Maier G, Rubino C, Hsu R, Pulmonary pharmacology & therapeutics . 2007,第5期

机译：4-11岁哮喘小儿患者中（R）-丁烯醇和（S）-丁烯醇的群体药代动力学
3. An unusual cause of Steven-Johnson Syndrome [J] . Claudia De Guido, Adriana Calderaro, Maria Beatrice Ruozi, Acta bio-medica: Atenei Parmensis . 2020,第1期

机译：史蒂文 - 约翰逊综合征的一个不寻常的原因
4. Usefulness of Spectral Analysis of Respiratory Rate Variability to Help in Pediatric Sleep Apnea-Hypopnea Syndrome Diagnosis [C] . Verónica Barroso-García, Gonzalo C. Gutiérrez-Tobal, Leila Kheirandish-Gozal, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

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5. Pediatric Germline Predispositions to Myelodisplastic Syndrome, Expert Guidance for the Initial Evaluation and Management of SAMD9 and SAMD9L Variants, and the Importance of Database Development for These Rare Syndromes [D] . Nelson, Catherine. 2021

机译：小儿种芽髓倾向于骨髓性综合征，初步评估和管理的专家指导和SAMD9和SAMD9L变体的重要性，以及数据库开发对这些罕见综合征的重要性
6. Case Report: Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence [O] . Bhawna Sharma, Raghavendra Bakki Sannegowda, Pankaj Gandhi, 1991

机译：病例报告：卡马西平治疗后史蒂文·约翰逊综合征和神经安定性恶性综合征的合并：罕见
7. Steven-Johnson Syndrome in Child [O] . Ramona Mihaela Nedelcuta, Vlad Dumitru Baleanu, Dragos Virgil Davitoiu, 2019

机译：史蒂文 - 约翰逊综合征在孩子

A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption

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