Application of highly efficient and lowly toxic bufadienolides screened from toad skin in lymphatic chemotherapy for colorectal cancer through a lymphatic metastatic model

He Changzheng; Zou Zhenyu; Xia Shaoyou; Xing Xiaowei; Hu Shidong; Hu Zilong; Li Yuxuan; Li Songyan; Zhang Hongliang; Yang Yu; Liu Yichen; Xu Xiaolei; Liu Boyan; Wang Yufeng; Xu Yingxin; Du Xiaohui

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Application of highly efficient and lowly toxic bufadienolides screened from toad skin in lymphatic chemotherapy for colorectal cancer through a lymphatic metastatic model

机译：通过淋巴化转移模型从淋巴化癌中的蟾蜍皮肤筛选高效且较低有毒的蟾蜍筛选

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Background: Lymph node metastasis (LNM) remains a major obstacle to treat colorectal cancer (CRC). Increasing evidences have suggested that bufadienolides contain several fractions displaying antitumor activity and may be applied in lymphatic chemotherapy. However, effects of the highly efficient and lowly toxic (HELT) bufadienolides on CRC in lymphatic chemotherapy have not been reported.

机译：背景：淋巴结转移（LNM）仍然是治疗结肠直肠癌（CRC）的主要障碍。提高证据表明，Bufdienolides含有几个级分，显示抗肿瘤活性，并且可以应用于淋巴化疗。然而，尚未报道高效且较低有毒（Helt）Bufdienolides对淋巴化疗中CRC的影响。

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来源
《International immunopharmacology》 |2019年第2019期|共11页
作者
He Changzheng; Zou Zhenyu; Xia Shaoyou; Xing Xiaowei; Hu Shidong; Hu Zilong; Li Yuxuan; Li Songyan; Zhang Hongliang; Yang Yu; Liu Yichen; Xu Xiaolei; Liu Boyan; Wang Yufeng; Xu Yingxin; Du Xiaohui;
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作者单位

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Capital Med Univ Beijing Chaoyang Hosp Dept Hernia &

Abdominal Wall Surg Beijing 100043 Peoples;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Capital Med Univ Beijing Chaoyang Hosp Dept Gen Surg Beijing 100020 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Patient Admiss Management Beijing 100853 Peoples R;

Chinese Gen Hosp Peoples Liberat Army Inst Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Gen Hosp Peoples Liberat Army Dept Gen Surg 28 Fuxing Rd Beijing 100853 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Bufadienolides; Colorectal cancer; Emulsion; Lymph node metastasis; Lymphatic chemotherapy;

机译：Bufdienolides;结肠直肠癌;乳液;淋巴结转移;淋巴化疗;

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专利

1. Application of highly efficient and lowly toxic bufadienolides screened from toad skin in lymphatic chemotherapy for colorectal cancer through a lymphatic metastatic model [J] . He Changzheng, Zou Zhenyu, Xia Shaoyou, International immunopharmacology . 2019,第期

机译：通过淋巴化转移模型从淋巴化癌中的蟾蜍皮肤筛选高效且较低有毒的蟾蜍筛选
2. Chemical profiling and cytotoxicity assay of bufadienolides in toad venom and toad skin [J] . Meng Qiong, Yau Lee-Fong, Lu Jing-Guang, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2016,第Null期

机译：蟾毒和蟾蜍皮中布法非烯内酯的化学分析和细胞毒性测定
3. Chemical profiling and cytotoxicity assay of bufadienolides in toad venom and toad skin [J] . Meng Qiong, Yau Lee-Fong, Lu Jing-Guang, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2016,第Null期

机译：在蟾蜍毒液和蟾蜍皮肤中Bufdienolides的化学分析和细胞毒性测定
4. Laser 3D-modeling of the image of the LYVE-1 marker expression in skin lymphatic vessels and prelymphatics in patients with urticaria pigmentosa [C] . Svetlana Viktorovna Michurina, Svechnikova Natalia Nikolaevna, Andrey Yurievich Letyagin, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：色素性荨麻疹患者皮肤淋巴管和前淋巴管中LYVE-1标记表达图像的激光3D建模
5. Controlled trans -lymphatic delivery of chemotherapy for the treatment of lymphatic metastasis in lung cancer [D] . Liu, Jiang. 2008

机译：控制跨晶递送化疗治疗肺癌淋巴结转移的治疗
6. Evaluation of lymphatic flow pattern using indocyanine green fluorescence imaging in a highly metastatic mouse model [O] . Masashi Yamamoto, Kohei Taniguchi, Tomo Tominaga, 2021

机译：高转移小鼠模型中使用吲哚菁绿荧光成像的淋巴流模式评价
7. Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia [O] . K.S. Schwab, A. Heine, T. Weimann, 2016

机译：Nivolumab治疗难治性转移性鳞状细胞癌和慢性淋巴细胞白血病患者溶血性贫血的发生

Application of highly efficient and lowly toxic bufadienolides screened from toad skin in lymphatic chemotherapy for colorectal cancer through a lymphatic metastatic model

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