• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International clinical psychopharmacology >Off-label antidepressant prescription in pediatric outpatients based on China Food and Drug Administration and Food and Drug Administration regulations: a Chinese retrospective study
【24h】

Off-label antidepressant prescription in pediatric outpatients based on China Food and Drug Administration and Food and Drug Administration regulations: a Chinese retrospective study

机译：基于中国食品和药物管理和食品和药物管理局的小儿外留剂的抗抑郁药处方：中国回顾性研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The objective of this study was to evaluate the prevalence and relative risk of off-label prescription of antidepressants in Chinese pediatric outpatients according to China Food and Drug Administration (C-FDA) and USFDA regulations. Medical records of 18459 pediatric outpatients were identified between 2013 and 2015. Patient characteristics, prevalence of off-label antidepressant prescriptions, and relative risk factors associated with off-label prescribing were analyzed. The results indicate that patients aged from 12 to 17 years account for 88.1% of antidepressant prescriptions, with the most commonly prescribed being sertraline (41.4%). In total, 90.0 and 84.1% of antidepressant prescriptions were off-labeled according to C-FDA and USFDA, respectively, and off-label indications was the most frequent type in this study. Depression was the most common indication for antidepressant treatment, followed by bipolar disorder and schizophrenia. Patients aged 12-17 years diagnosed with bipolar affective disorder have a high risk of off-label antidepressant prescription according to C-FDA regulations. Patients diagnosed with obsessive-compulsive disorder have a low risk of off-label antidepressant prescription according to both regulations. Therefore, future studies are recommended to collect evidence to safeguard appropriate prescribing of off-label antidepressants among pediatric patients.
机译：本研究的目的是根据中国食品和药物管理局（C-FDA）和USFDA法规，评估中国小儿外门诊抗抑郁药的患病率和相对风险。分析了18459年的医疗记录2013年至2015年间鉴定了患者特征，患者特征，缺口抗抑郁药处的患病率，以及与偏标规定相关的相对危险因素。结果表明，12至17岁的患者占88.1％的抗抑郁症处方，最常见的是萨满碱（41.4％）。总共，90.0和84.1％的抗抑郁症处于根据C-FDA和USFDA脱掉标记，并且偏离标签适应症是本研究中最常见的类型。抑郁症是抗抑郁药治疗的最常见迹象，其次是双相障碍和精神分裂症。 12-17岁的患者诊断患有双极情感障碍的风险很高，根据C-FDA规定具有高标签抗抑郁药处方的风险。诊断出强迫症的患者根据这两个法规对非标签抗抑郁药处方的风险很低。因此，建议未来的研究收集证据，以保障儿科患者中的适当处方抗抑郁药。

著录项

  • 来源
  • 作者

    Deng Shuhua; Zhu Xiuqing; Sun Bin; Hu Jinqing; Shang Dewei; Chen Weijia; Lu Haoyang; Ni Xiaojia; Zhang Ming; Wang Zhanzhang; Wen Yuguan; Qiu Chang;

  • 作者单位

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Neuropsychiat Res Inst;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

    Guangzhou Med Univ Guangzhou Huiai Hosp Affiliated Brain Hosp Dept Clin Pharm 36 MingXin Rd;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    antidepressants; China Food and Drug Administration and Food and Drug Administration regulations; children and adolescents; off-label; pediatric;

    机译：抗抑郁药;中国食品和药品管理局;儿童和青少年;非标签;儿科;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号