...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Genomics >Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women
【24h】

Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

机译：内质网氨基肽酶1和2的基因变异，以及17,255名初始健康女性中血压进展和入射高血压的风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic-epidemiological data are available on genetic variation within ERAP and hypertension risk. The association of 45 genetic variants of ERAP1 and ERAP2 was investigated in 17,255 Caucasian female participants from the Women’s Genome Health Study. All subjects were free of hypertension at baseline. During an 18-year follow-up period, 10,216 incident hypertensive cases were identified. Multivariable linear, logistic, and Cox regression analyses were performed to assess the relationship of genotypes with baseline BP levels, BP progression at 48 months, and incident hypertension assumingan additive genetic model. Linear regression analyses showed associations of four tSNPs (ERAP1-. rs27524; ERAP2: rs3733904, rs4869315, and rs2549782; all p < 0.05) with baseline systolic BP levels. Three tSNPs (ERAP1-. rs27851, rs27429, and rs34736, allp < 0.05) were associated with baseline diastolic BP levels. Multivariable logistic regression analysis showed that ERAP1 rs27772 was associated with BP progression at 48 months (p = 0.0366). Multivariable Cox regression analysis showed an association ofthree tSNPs (ERAP1: rs469783 and rsl0050860; ERAP2: rs2927615; all p < 0.05) with risk of incident hypertension. Analyses of dbGaP for genotype-phenotype association and GTEx Portal for gene expression quantitative trait loci revealed five tSNPs with differential association of BP and nine tSNPs with lower ERAP1 and ERAP2 mRNA expression levels, respectively. The present study suggests that ERAP1 and ERAP2 gene variation may be useful for risk assessment of BP progression and the development of hypertension.
机译：最近的研究表明内质网氨基肽酶（ERAP）在血压（BP）稳态中的重要性。迄今为止，没有大的前瞻性遗传流行病学数据可用于蚀刻和高血压风险内的遗传变异。来自女性基因组卫生研究的17,255名白种人女性参与者，研究了45种遗传变异的eRAP1和ERAP2的遗传变异。所有受试者在基线上没有高血压。在18年的随访期间，确定了10,216份入射的高血压病例。进行多变量线性，逻辑和COX回归分析，以评估基因型与基线BP水平，48个月进展的基因型的关系，以及入射高血压假设添加剂遗传模型。线性回归分析显示了四个TSNP的关联（RS27524; ERAP2：RS3733904，RS4869315和RS2549782;所有P <0.05），具有基线收缩性BP水平。三个TSNP（ERAP1-。RS27851，RS27429和RS34736，ALLP <0.05）与基线舒张性BP水平相关。多变量逻辑回归分析表明，ERAP1 RS27772在48个月内与BP进展相关联（P = 0.0366）。多变量的Cox回归分析显示Three Tsnps关联（ERAP1：RS469783和RSL0050860; ERAP2：RS2927615;所有P <0.05），发生异性高血压风险。基因型 - 表型关联和基因表达的GTEX门户的DBGAP分析分别揭示了五个TSnP，分别具有差异均匀的BP和九个TSNP与eRAP1和ERAP2 mRNA表达水平的差异。本研究表明，ERAP1和ERAP2基因变异可用于BP进展的风险评估和高血压的发展。

著录项

  • 来源
    《International Journal of Genomics》 |2018年第1期|共9页
  • 作者

    Robert Y. L. Zee; Alicia Rivera; Yaritza Inostroza;

  • 作者单位

    Department of Pediatric Dentistry Tufts University School of Dental Medicine Boston MA 02111 USA;

    Division of Endocrinology Diabetes and Hypertension Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston MA 02115 USA;

    Division of Endocrinology Diabetes and Hypertension Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston MA 02115 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号