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首页> 外文期刊>Advanced Science Letters >Micro-Patterned Surface Modification of Poly(dimethylsiloxane) (PDMS) Substrates for Tissue Engineering
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Micro-Patterned Surface Modification of Poly(dimethylsiloxane) (PDMS) Substrates for Tissue Engineering

机译：用于组织工程的聚二甲基硅氧烷（PDMS）基板的微图案表面改性

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摘要

Low energy metal ion implantation of poly(dimethylsiloxane) (PDMS) films simultaneously allows for the creation of complex and tuneable topographical features at the surface, while also enhancing the biocompatibility of the surface for biological applications. PDMS thick films were implanted with Mg, Ta, and Fe at constant dose. Cells cultured on all of the modified surfaces enjoyed an increase in viable cell count of over 440% when compared to the pristine surface, with the Fe implanted surface showing a 600% increase with a substantial increase in surface energy, which was reflected by the increased contact angle. This was achieved without any biochemical patterning requiring multiple processing steps, complex chemistries, or clean room facilities. The rapid prototyping and ease of creation makes this technique useful for the fabrication of selective and functionalised substrates and scaffolds for in depth bio-analytic studies, implants, and device components. The results of surface energy studies, cross-sectional transmission electron microscopy, and compositional analysis, as well as initial biocompatibility testing, are presented.
机译：聚二甲基硅氧烷（PDMS）膜的低能金属离子注入同时允许在表面创建复杂且可调整的形貌特征，同时还增强了生物应用表面的生物相容性。在PDMS厚膜中以恒定剂量注入Mg，Ta和Fe。与原始表面相比，在所有经过修饰的表面上培养的细胞的存活细胞数均增加了440％以上，其中植入Fe的表面显示出600％的增加，表面能显着增加，这反映在增加的表面能上接触角。无需任何生物化学图案即可实现，而无需进行多个处理步骤，复杂的化学过程或无尘室设施。快速的原型制作和易于创建使该技术可用于深度生物分析研究，植入物和设备组件的选择性和功能化基质和支架的制造。介绍了表面能研究，横截面透射电子显微镜和成分分析以及初始生物相容性测试的结果。

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