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首页> 外文期刊>International journal of gynecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics >A systematic review and meta‐analysis of venous thrombosis risk among users of combined oral contraception
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A systematic review and meta‐analysis of venous thrombosis risk among users of combined oral contraception

机译：口服避孕药物中静脉血栓形成风险的系统审查和荟萃分析

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Abstract Background Combined oral contraceptives ( COC s) containing various progestogens could be associated with differential risks for venous thromboembolism ( VTE ). Objective To evaluate the comparative risks of VTE associated with the use of low‐dose (less than 50?μg ethinyl estradiol) COC s containing different progestogens. Search strategy PubMed and the Cochrane Library were searched from database inception through September 15, 2016, by combining search terms for oral contraception and venous thrombosis. Selection criteria Studies reporting VTE risk estimates among healthy users of progestogen‐containing low‐dose COC s were included. Data collection and analysis A random‐effects model was used to generate pooled adjusted risk ratios and 95% confidence intervals; subgroup and sensitivity analyses assessed the impact of monophasic‐ COC use and study‐level characteristics. Main results There were 22 articles included in the analysis. The use of COC s containing cyproterone acetate, desogestrel, drospirenone, or gestodene was associated with a significantly increased risk of VTE compared with the use of levonorgestrel‐containing COC s (pooled risk ratios 1.5–2.0). The analysis restricted to monophasic COC formulations with 30?μg of ethinyl estradiol yielded similar findings. After adjustment for study characteristics, the risk estimates were slightly attenuated. Conclusions Compared with the use of levonorgestrel‐containing COC s, the use of COC s containing other progestogens could be associated with a small increase in risk for VTE .
机译：摘要背景含有各种孕激素的口腔避孕药（COC S）可能与静脉血栓栓塞（VTE）的差异风险相关。目的评价与使用不同孕激素的低剂量（小于50Ω乙炔雌二醇）COC S的VTE的比较风险。通过组合口腔避孕和静脉血栓形成的搜索条件，从数据库成立中搜索了搜索战略。选择标准研究报告孕激素的低剂量COC S健康使用者之间的VTE风险估计。数据收集和分析使用随机效应模型来产生汇集的调整风险比和95％的置信区间;亚组和敏感性分析评估了单一的使用和研究水平特征的影响。主要结果分析中有22篇文章。与使用含有左炔诺孕烯的COC S（合并风险比1.5-2.0）相比，使用含Cyproterone醋酸酯醋酸酯醋酸酯醋酸酯醋酸酯，Desogestrel，Draphir酮或粘滞与VTE的风险显着增加有关。限制与30≤μg乙炔雌二醇的单相COC制剂的分析产生了类似的结果。调整研究特征后，风险估计略有衰减。结论与含有左旋霉素的COC S相比，使用含有其他孕激素的COC S可能与VTE的风险较小有关。

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