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首页> 外文期刊>International journal of immunogenetics >CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box
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CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box

机译：CCR5和CCR5Δ32在细菌和寄生感染中：艾滋病毒盒外的思维趋化因子受体

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Abstract The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year, the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 infection. These findings led to extensive research regarding the CCR5, culminating in critical scientific advances, such as the development of CCR5 inhibitors for the treatment of HIV infection. Recently, the research landscape surrounding CCR5 has begun to change. Different research groups have realized that, since CCR5 has such important effects in the chemokine system, it could also affect other different physiological systems. Therefore, the effect of reduced CCR5 expression due to the presence of the CCR5Δ32 variant began to be further studied. Several studies have investigated the role of CCR5 and the impacts of CCR5Δ32 on autoimmune and inflammatory diseases, various types of cancer, and viral diseases. However, the role of CCR5 in diseases caused by bacteria and parasites is still poorly understood. Therefore, the aim of this article is to review the role of CCR5 and the effects of CCR5Δ32 on bacterial (brucellosis, osteomyelitis, pneumonia, tuberculosis and infection by Chlamydia trachomatis ) and parasitic infections (toxoplasmosis, leishmaniasis, Chagas disease and schistosomiasis). Basic information about each of these infections was also addressed. The neglected role of CCR5 in fungal disease and emerging studies regarding the action of CCR5 on regulatory T cells are briefly covered in this review. Considering the “renaissance of CCR5 research,” this article is useful for updating researchers who develop studies involving CCR5 and CCR5Δ32 in different infectious diseases.
机译：摘要1996年作为主要HIV-1共同受体报道了CCR5分子。在同年，CCR5Δ32遗传变异被描述为对HIV-1感染的强烈保护因子。这些调查结果导致了关于CCR5的广泛研究，最终在关键科学进步，例如CCR5抑制剂的开发治疗HIV感染。最近，CCR5周围的研究景观已经开始改变。不同的研究组已经意识到，由于CCR5在趋化因素系统中具有如此重要的效果，因此它也可能影响其他不同的生理系统。因此，进一步研究了CCR5表达引起的降低的影响开始。几项研究已经研究了CCR5的作用和CCR5Δ32对自身免疫和炎症性疾病的影响，各种类型的癌症和病毒疾病。然而，CCR5在细菌和寄生虫引起的疾病中的作用仍然很糟糕。因此，本文的目的是审查CCR5的作用以及CCR5Δ32对细菌（Brucellosis，骨髓炎，肺炎，结核病和Chamydia Trachomatis的感染）和寄生感染（弓形虫病，Leishmaniaisis，Chagas疾病和血吸虫病）的作用。还解决了关于这些感染中的每一个的基本信息。本综述，简要介绍了CCR5在真菌疾病中的忽视作用以及关于CCR5对调节性T细胞的作用的新出现研究。考虑到“CCR5研究的文艺复兴”，本文对更新研究人员的研究人员有用，这些研究人员在不同的传染病中开发涉及CCR5和CCR5Δ32的研究。

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