...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >Current immunogenetic predisposition to tuberculosis in the Moroccan population
【24h】

Current immunogenetic predisposition to tuberculosis in the Moroccan population

机译：目前摩洛哥人口肺结核的免疫原性易感性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Tuberculosis ( TB ) is a serious infectious disease that kills approximately two million people per year, particularly in low‐ and middle‐income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB . Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB , particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.
机译：综述结核病（TB）是一种严重的传染病，每年杀死大约200万人，特别是在低收入和中等收入国家。许多遗传流行病学研究已经在全球许多族裔群体进行，并强调了遗传环境对TB分布的关键影响。已经鉴定了许多与抗TB相关或易感性相关的候选基因。在摩洛哥，TB仍然是一个主要的公共卫生问题，各种临床，微生物和发病率分布的观察受到遗传背景和外部环境的严重影响。摩洛哥几乎与其他北非国家的临床概况几乎相同，主要是在欧洲，亚洲人或美国人的疾病相比时比肺部形式更多的肺形式。此外，检查摩洛哥TB患者的联系分析研究鉴定了一种独特的染色体区域，其具有强烈关联与收缩结核病的风险。发现相关的摩洛哥人群中的其他基因似乎主要参与调节先天免疫力。在本次审查中，我们评估摩洛哥免疫原性研究中报道的主要候选基因，并在TB中讨论其更新的作用，特别是在对结核分枝杆菌（MTB）感染的免疫应答的第一阶段。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号