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首页> 外文期刊>International journal of geriatric psychiatry >The association between orthostatic hypotension and dementia: A meta‐analysis of prospective cohort studies
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The association between orthostatic hypotension and dementia: A meta‐analysis of prospective cohort studies

机译：原外胚性低血压与痴呆症之间的关联：预期队列研究的荟萃分析

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Objectives As for the association between orthostatic hypotension (OH) and dementia, results of published studies are inconsistent; therefore, current substantive conclusions have yet been obtained. This meta‐analysis was conducted in hopes of producing progress in this topic. Methods A systematic database search was performed towards electronic databases including Chinese Biomedical Database, PubMed, Web of Science, Wiley Online Library, ScienceDirect, and the Cochrane Library. Five prospective cohort studies were included. Summary hazard ratio (HR) estimates with 95% confidence intervals (CIs) were calculated by random‐effects model. Statistical heterogeneity was assessed with the Cochran Q test and I 2 statistic. A sensitivity analysis was also conducted in this meta‐analysis. Results A 22.4% higher prevalence of dementia in subjects with OH was obtained (adjusted pooled HR was 1.224; 95% CI: 1.106‐1.354; P ??.001). This meta‐analysis also showed significant associations between OH and 2 dementia subtypes: Alzheimer disease (adjusted pooled HR was 1.175; 95% CI: 1.022‐1.351; P ?=?.023) and Vascular dementia (adjusted pooled HR was 1.403; 95% CI: 1.042‐1.889; P ?=?.026), respectively. Conclusions Orthostatic hypotension is positively associated with the overall prevalence of dementia, and it may contribute to the prevalence of Alzheimer disease and Vascular dementia as well.
机译：目的是出版物间低血压（OH）和痴呆之间的关联，发表研究的结果不一致;因此，尚未获得当前的实质性结论。该荟萃分析是为了在本主题中产生进展而进行的。方法对电子数据库进行系统数据库搜索，包括中国生物医学数据库，PubMed，Science，Wiley在线图书馆，ScieCentirect和Cochrane图书馆。包括五项预期队列研究。发明内容通过随机效应模型计算危险比（HR）具有95％置信区间（CIS）的估计。用Cochran Q测试和I 2统计评估统计异质性。在该荟萃分析中也进行了敏感性分析。结果获得OH的受试者的痴呆症的患病率高22.4％（调整后的HR为1.224; 95％CI：1.106-1.354; p？＆ 001）。该荟萃分析还显示出OH和2个痴呆亚型之间的显着关联：阿尔茨海默病（调整后的汇集HR为1.175; 95％CI：1.022-1.351; p？= 023）和血管痴呆（调整后的汇集人力资源为1.403; 95 ％CI：1.042-1.889; p？=Δ.026）。结论原位低血压与痴呆症的总体流行呈正相关，也可能有助于阿尔茨海默病和血管痴呆的患病率。

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