A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

Danny L. Costantini; Reza Vali; Susan McQuattie; Jeffrey Chan; Angela Punnett; Shiela Weitzman; Amer Shammas; Martin Charron

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A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

机译：18F-FLT PET / CT在儿科淋巴瘤中的试验研究

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We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.

机译：我们对儿科淋巴瘤的18F-FLT / CT进行了观测试验研究。八名患者患有一定的28F-FDG PET / CT接受了18F-FLT PET / CT的成像。没有观察到对18F-FLT的立即不良反应。与18F-FDG相比，骨髓和肝脏18°F-FLT摄取显着高（18F-FLT SUV 8.6±0.6和5.0±0.3，而不是18F-FDG SUV 1.9±0.1和3.4±0.7，P <0.05 ）。总共15例，平均为15°F-FDG和18F-FLT SUV分别评估了15个病变分别为2.6±0.1和2.0±0.4。观察到反应性淋巴结和胸腺中的非特异性摄取。未来的研究为了评估18F-FLT PET / CT在儿科淋巴瘤中的临床用途。

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《International journal of molecular imaging》 |2016年第2016期|共5页
作者
Danny L. Costantini; Reza Vali; Susan McQuattie; Jeffrey Chan; Angela Punnett; Shiela Weitzman; Amer Shammas; Martin Charron;
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Department of Medical Imaging University of Toronto 263 McCaul Street 4th Floor Toronto ON;

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正文语种 eng
中图分类诊断学;
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1. A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma [J] . Danny L. Costantini, Reza Vali, Susan McQuattie, International journal of molecular imaging . 2016,第期

机译：18F-FLT PET / CT在儿科淋巴瘤中的试验研究
2. Exploring Spatial Overlap of High-Uptake Regions Derived From Dual Tracer PET/CT Imaging Using 18F-FDG and 18F-FLT in Non-Small Cell Lung Cancer Patients: A Prospective Pilot Study [J] . Liu J., Li C., Hu M., International Journal of Radiation Oncology, Biology, Physics . 2017,第1期

机译：使用18F-FDG和18F-FLT在非小细胞肺癌患者中探索从双跟踪宠物/ CT成像的高摄取区域的空间重叠：一项潜在的试点研究
3. 18F-FLT PET/CT as an imaging tool for early prediction of pathological response in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy: a pilot study [J] . Flavio Crippa, Roberto Agresti, Marco Sandri, European Journal of Nuclear Medicine and Molecular Imaging . 2015,第6期

机译：18F-FLT PET / CT作为影像学工具，可早期预测接受新辅助化疗的局部晚期乳腺癌患者的病理反应
4. A pilot study of the prognostic significance of metabolic tumor size measurements in PET/CT imaging of lymphomas [C] . Maria Kallergi, Maria Botsivali, Nikolaos Politis, Conference on biomedical applications in molecular, structural, and functional imaging . 2015

机译：代谢肿瘤大小测量对淋巴瘤PET / CT成像的预后意义的初步研究
5. Web-Based evidence based practice educational intervention to improve EBP competence among BSN-prepared pediatric bedside nurses: A mixed methods pilot study [D] . Laibhen-Parkes, Natasha 2014

机译：基于网络的循证实践教育干预以提高BSN准备的儿科床边护士的EBP能力：一项混合方法的初步研究
6. A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma [O] . Danny L. Costantini, Reza Vali, Susan McQuattie, 2016

机译：小儿淋巴瘤18F-FLT PET / CT的初步研究
7. Exploring Spatial Overlap of High-Uptake Regions Derived From Dual Tracer PET/CT Imaging Using 18F-FDG and 18F-FLT in Non–Small Cell Lung Cancer Patients: A Prospective Pilot Study [O] . J. Liu, C. Li, M. Hu, 2017

机译：使用18F-FDG和18F-FLT在非小细胞肺癌患者中探索从双跟踪宠物/ CT成像的高摄取区域的空间重叠：一项潜在的试点研究

A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

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