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首页> 外文期刊>International ophthalmology >Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis
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Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis

机译：与视网膜血缘性增殖的ARM2 / LOC387715 A69S，CFH Y402H和CFH I62V多态性的关联与典型的年龄相关性黄斑变性：META分析

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Abstract Purpose To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls. Methods Heterogeneity of studies was evaluated using Cochran’s Q test and I -square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA. Results Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60–2.18) for GT versus GG, 3.52 (95% CI 1.25–9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22–4.29) for GA versus AA, 1.00 (95% CI 0.25–4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35–0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22–0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes ( P ? Conclusion This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes.
机译：摘要目的，用于比较武器2 / LOC38715 A69S，CFH Y402H和CFH I62V基因型关联研究结果的出版结果，诊断为视网膜血管性增殖（RAP）与新生血管年龄相关的黄斑（AMD）或健康对照组。方法使用Cochran的Q测试和I-Square指数评估研究的异质性。要修改变量中的异质性，我们使用了随机效果模型。使用STATA进行META分析。结果1076名新生血管患者，222例RAP病例和2276名对照科目，包括四项研究。用于GT的GT与GG，3.52（95％CI 1.25-9.91）的GA与GG武器2，0.98（95％CI 0.22-4.29）的GA与GG ARM，3.52（95％CI 1.25-9.91）为1.15（95％CI 0.60-2.18）。 AA，1.00（95％CI 0.25-4.02）用于GG与AA CFHI62V，0.57（95％CI 0.35-0.93），用于CT与TT CFH Y402H，0.40（95％CI 0.22-0.74），用于CC与TT CFH Y402H。回归分析表明，与CFH基因型相比，ARM2 TT基因型对RAP与AMD具有统计学显着的影响（P？结论该荟萃分析，与CFH Y402H和I62V基因型相比，RAP案例中的武器2基因型的较强效果。

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