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首页> 外文期刊>Acute pain: international journal of acute pain management >Preemptive analgesia with epidural bupivacaine plus fentanyl in gynaecological surgery - Effects on serum interleukin-6 concentrations
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Preemptive analgesia with epidural bupivacaine plus fentanyl in gynaecological surgery - Effects on serum interleukin-6 concentrations

机译：硬膜外布比卡因联合芬太尼先发性镇痛在妇科手术中的应用-对血清白介素6浓度的影响

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Purpose: The aim of this study was to evaluate preemptive analgesia and its influence on interleukin-6 (IL-6) levels. Methods: Thirty patients scheduled for hysterectomy were randomised in two groups to receive 13 ml bupivacaine 0.25% plus fentanyl (100 < mu >g) before incision and 15 ml of saline after incision (group I, GI), or 15 ml of saline before incision and 13 ml bupivacaine 0.25% plus fentanyl (100 < mu >g) after incision (group II, GII). General anaesthesia was performed using propofol/pancuronium/O2/isoflurane. Postoperative analgesia consisted of epidural bolus doses of 4 ml bupivacaine 0.25% plus fentanyl (50 < mu >g) or dipyrone i.v. on demand. Pain was assessed by visual analogue scale (VAS). IL-6 levels were quantified during the study. Results: Patients in group I had significantly less pain only at arrival in recovery room. The requirements for rescue analgesia were similar in both groups and there were no significant differences in IL-6 concentrations. Conclusions: This study showed no preemptive effect of epidural fentanyl plus bupivacaine on postoperative pain and stress response as measured by IL-6 concentrations. < copyright > 2002 Elsevier Science B.V. All rights reserved.
机译：目的：本研究的目的是评估先发镇痛及其对白介素6（IL-6）水平的影响。方法：将计划行子宫切除术的30例患者随机分为两组，分别在切口前接受13 ml 0.25％布比卡因加芬太尼（100 g），切口后接受15 ml生理盐水（I，GI组），或在切口前接受15 ml生理盐水。切口（II组，GII），并在切口后加0.25％的13ml布比卡因加0.25％芬太尼（100μg）。使用异丙酚/潘库溴铵/ O 2 /异氟醚进行全身麻醉。术后镇痛由硬膜外推注剂量的4 ml 0.25％布比卡因加芬太尼（50 <μg）或潘生酮i.v.一经请求。通过视觉模拟量表（VAS）评估疼痛。在研究期间定量IL-6水平。结果：第一组患者仅在到达康复室时疼痛明显减轻。两组的急救镇痛要求相似，并且IL-6浓度无明​​显差异。结论：该研究显示，通过IL-6浓度测量，硬膜外芬太尼联合布比卡因对术后疼痛和应激反应无先发作用。 <版权> 2002 Elsevier Science B.V.保留所有权利。

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