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首页> 外文期刊>International Urology and Nephrology >MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats
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MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats

机译：MST3（哺乳动物STE20样蛋白激酶3），一种新的基因，涉及离子稳态和自发性高血压大鼠中血压的肾调节

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摘要

Defective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-related kinase (SPAK) and oxidative stress-response protein 1 (OSR1), are regulators of cell volume, ion transport, and hypertension. The aim of this study was to investigate whether mammalian sterile 20-like protein kinase 3 (MST3), which is also a stress-regulated kinase, is involved in the development of hypertension. MST3 expression was compared in Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) kidneys. MST3 expression was markedly reduced in principal cells of the collecting ducts from the renal inner medulla of SHR. The downregulation of MST3 expression was observed before and after the onset of hypertension in SHR. Mice fed high-salt diets (HS) exhibited a significant increase in MST3 protein level. This is the first study reporting that MST3, a Ste20-like kinase, exerts a conserved regulatory role in sodium homeostasis after high-salt diet and in the development of hypertension.
机译：肾脏盐和水排泄有缺陷，以及增加的盐摄入量，经常有助于高血压。最近的研究表明，STE20家族激酶，例如富含丙氨酸 - 丙氨酸富含的STE20相关激酶（SPAK）和氧化应激反应蛋白1（OSR1），是细胞体积，离子转运和高血压的调节因子。该研究的目的是研究哺乳动物无菌20样蛋白激酶3（MST3），也是一种应激调节激酶，参与高血压的发育。在Wistar-Kyoto（Wky）和自发性高血压大鼠（SHR）肾脏中比较了MST3表达。来自REN的肾内髓质的收集管道的主要细胞中，MST3表达明显减少。在SHR中高血压发作之前和之后观察到MST3表达的下调。喂养高盐饮食（HS）的小鼠表现出MST3蛋白质水平的显着增加。这是第一项研究报告，MST3，STE20样激酶，在高盐饮食和高血压发展后，在高盐宿舍和高血压发展中发挥保守的调节作用。

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