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首页> 外文期刊>Investigative radiology >Subacute Infarct Volume With Edema Correction in Computed Tomography Is Equivalent to Final Infarct Volume After Ischemic Stroke Improving the Comparability of Infarct Imaging Endpoints in Clinical Trials
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Subacute Infarct Volume With Edema Correction in Computed Tomography Is Equivalent to Final Infarct Volume After Ischemic Stroke Improving the Comparability of Infarct Imaging Endpoints in Clinical Trials

机译：在计算机断层扫描中具有水肿校正的亚急性梗塞体积相当于缺血性卒中后的最终梗塞体积，提高临床试验中梗塞成像终点的可比性

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摘要

Objectives Final infarct volume is regularly used as an end point of tissue outcome in stroke trials; however, the reported volumes are most commonly derived from early follow-up imaging. Those volumes are significantly impaired by ischemic edema, which causes an overestimation of the true final lesion volume. As net water uptake within ischemic brain can be quantified densitometrically in computed tomography (CT) as recently described, we hypothesized that the final lesion volume can be better estimated by correcting the lesion volume in early follow-up for the corresponding proportion of edema.
机译：目标最终梗塞体积定期用作中风试验中组织结果的终点; 然而，报告的卷最常衍生自早期后续成像。 这些体积因缺血性水肿而显着损害，导致真正的最终病变量的高估。 随着缺血性大脑内的净水吸收可以在最近描述的计算机断层扫描（CT）中致密化，我们假设可以通过校正早期后续的后续比例的水肿的后续后续的病变体积来估计最终病变体积。

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