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首页> 外文期刊>Acute pain: international journal of acute pain management >An audit of the safety and effectiveness of an alfentanil:morphine mixture in the postanaesthesia care unit
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An audit of the safety and effectiveness of an alfentanil:morphine mixture in the postanaesthesia care unit

机译：麻醉后监护病房中阿芬太尼：吗啡混合物的安全性和有效性审计

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Background: After an initial clinical investigation of the effectiveness of an alfentanil-morphine mixture (AM) for the treatment of postoperative pain in the recovery setting, an audit was conducted to look at the effectiveness, safety and incidence of adverse opioid-related side effects of this mixture compared with morphine (M) alone. Assessment of effectiveness included the time and dose required to achieve patient comfort, the time to discharge from the postanaesthesia care unit (PACU) and pain scores; assessment of safety and side effects included measurement of sedation scores, oxygen saturation and respiratory rate as well as incidence of nausea and vomiting, and pruritus. Methods: A total of 453 patients were recruited: the M group (221 patients) received a standard IV morphine regimen (morphine concentration 1 mg/ml; bolus doses of between 0.5 and 4 ml IV given every 3 min as needed by nursing staff according to the hospital protocol梥ee Appendix A); the AM group (232 patients) received a similar IV regimen using the alfentanil:morphine mixture (alfentanil 50 mug and morphine 0.75 mg/ml; bolus doses given as for morphine). Results: In the M group, the mean time to comfort was 40.9 3+-34 min whilst in the AM group, it was 32.8+-26min (significant at p = 0.004). The mean (S.D.) volume required to achieve comfort was similar and the mean time to discharge from the PACU was 105.3 +-75 min for the M group and 88.4+-55min for the AM group (p = 0.5). Neither the sedation scores or pain scores at comfort differed significantly between the groups.
机译：背景：在初步临床研究了阿芬太尼-吗啡混合物（AM）在恢复环境中治疗术后疼痛的有效性后，进行了审核，以查看阿片类药物相关不良副作用的有效性，安全性和发生率与单独的吗啡（M）相比有效性评估包括达到患者舒适度所需的时间和剂量，麻醉后护理单位（PACU）出院的时间以及疼痛评分;安全性和副作用的评估包括镇静评分，氧饱和度和呼吸频率的测量，以及恶心，呕吐和瘙痒的发生率。方法：总共招募了453名患者：M组（221名患者）接受标准的吗啡静脉注射方案（吗啡浓度1 mg / ml;按护理人员的需要每3分钟静脉推注0.5至4 ml静脉推注剂量）到医院规程附录A）; AM组（232例患者）使用阿芬太尼：吗啡混合物（阿芬太尼50杯和吗啡0.75 mg / ml;大剂量推定吗啡）接受了相似的静脉输注方案。结果：M组的平均舒适时间为40.9 3 + -34分钟，而AM组的平均舒适时间为32.8 + -26分钟（在p = 0.004时显着）。达到舒适所需的平均（S.D.）体积相似，M组从PACU排出的平均时间为105.3 + -75分钟，而AM组为88.4 + -55分钟（p = 0.5）。两组之间的镇静分数或疼痛分数均无显着差异。

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