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首页> 外文期刊>Acute pain: international journal of acute pain management >New options of non-opioids in acute pain management: The view of a pharmacologist
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New options of non-opioids in acute pain management: The view of a pharmacologist

机译：非阿片类药物在急性疼痛治疗中的新选择：药理学家的观点

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Cyclooxygenase inhibitors are of limited use in the perioperative setting. They are very well suited to reduce pain and suffering. However, cyclooxygenase inhibitors carry the risk of unwanted drug effects, a risk which so far has often limited their use. Traditional cyclooxygenase inhibitors, also termed non-steroidal, anti-inflammatory drugs (tNSAID), are known to cause GI-ulcers, interfere with blood coagulation and kidney function. They may provoke asthma like reactions (aspirin-likeasthma) and they may interfere with renal function, including acute renal failure in patientswith major blood (fluid) and electrolyte losses. Some of these drawbacks may be circumvented by using selective cyclooxygenase inhibitors (COX-2 inhibitors). In addition to their relative GI-safety, they are known to rarely precipitate asthma-like reactions and never interfere with blood coagulation. Regarding their effect on kidney function, they are comparable to non-selective inhibitors. On the other hand, they may increase the risk of thromboembolicevents following surgical intervention. Therefore, they must not be used in cardiovascular risk patients.
机译：环氧合酶抑制剂在围手术期中用途有限。它们非常适合减轻疼痛和痛苦。然而，环氧合酶抑制剂具有不希望的药物作用的风险，这种风险到目前为止通常已经限制了它们的使用。传统的环氧合酶抑制剂，也称为非甾体类抗炎药（tNSAID），已知会引起GI溃疡，干扰血液凝结和肾脏功能。它们可能引起类似哮喘的反应（阿司匹林样哮喘），并且可能干扰肾功能，包括大量血液（液体）和电解质流失的患者的急性肾衰竭。通过使用选择性环氧合酶抑制剂（COX-2抑制剂）可以避免其中一些缺点。除了其相对的胃肠道安全性外，已知它们很少引起哮喘样反应，并且从不干扰血液凝固。关于它们对肾功能的作用，它们与非选择性抑制剂相当。另一方面，它们可能会增加外科手术后血栓栓塞的风险。因此，不得将它们用于有心血管风险的患者。

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