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首页> 外文期刊>Echocardiography. >Early detection of cardiotoxicity by 3D speckle tracking imaging of area strain in breast cancer patients receiving chemotherapy
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Early detection of cardiotoxicity by 3D speckle tracking imaging of area strain in breast cancer patients receiving chemotherapy

机译：早期检测乳腺癌患者面积应变的3D散斑跟踪成像，接受化疗

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Abstract Eighty‐three breast cancer patients who underwent six cycles of EC chemotherapy regimen (epirubicin?+?cyclophosphamide) without symptoms and signs of heart disease were enrolled in the study. Three‐dimensional speckle tracking imaging technique (3D‐ STI ) was used to measure left ventricular global area strain ( GAS ), overall annular strain ( GCS ), overall longitudinal strain ( GLS ), and overall radial strain ( GRS ). Meanwhile, serum troponin T (Hs‐ cTnT ) was measured. The clinical value of each index on cardiotoxicity after chemotherapy was analyzed using the receiver operating characteristic ( ROC ) curve. Hs‐ cTnT increased from the early stage to the end during chemotherapy, but it was still in the normal range. During the mid‐chemotherapy and the end‐chemotherapy, GAS , GLS , GCS , and E/A significantly reduced, while the changes in LVESV , LVEDV , LVEF , and GRS were not significant after chemotherapy. Pearson correlation analysis showed a significant negative correlation between GAS and anthracycline doses ( r ?=??.772, P ??.01); GAS and Hs‐ cTnT were significantly negatively correlated ( P ??.05). The area under the curve ( AUC ) of GAS , GLS , GCS , and GRS are 0.815, 0.683, 0.645, and 0.585, respectively. A GAS of ?31.5% was used as the cutoff value for diagnosing left ventricular systolic dysfunction after receiving chemotherapy. The sensitivity of the previous parameters was 81.9%, and the specificity was 80.3%. Interobserver consistency analysis showed that 3D‐ STI strain parameter measurement has good repeatability. GAS has greater value in predicting early myocardial damage after anthracycline chemotherapy.
机译：摘要在研究中接受了六个循环的六个循环的六个乳腺癌患者（Epirubicin？+？环磷酰胺），没有症状和心脏病的迹象。三维散斑跟踪成像技术（3D-STI）用于测量左心室全球区域应变（气体），整体环形应变（GCS），整体纵向应变（GLS）和整体径向菌株（GRS）。同时，测量血清肌钙蛋白T（HS-CTNT）。使用接收器操作特性（ROC）曲线分析化疗后，各指标对化疗后心毒性的临床价值。 HS-CTNT在化疗期间从早期到末端增加，但它仍处于正常范围。在中间化疗和最终化疗，天然气，GLS，GCS和E / A显着减少，而叶丝，LVEDV，LVEF和GR的变化在化疗后没有显着。 Pearson相关性分析显示气体和蒽环霉素剂量之间的显着负相关（R？=。772，p？＆ 01）;气体和HS-CTNT显着地呈负相关（P≤1。05）。曲线（AUC）下的气体，GLS，GCS和GRS的区域分别为0.815,0.683,0.645和0.585。使用？31.5％的气体被用作在接受化学疗法后诊断左心室收缩功能障碍的截止值。先前参数的敏感性为81.9％，特异性为80.3％。 Interobserver一致性分析表明，3D-STI应变参数测量具有良好的重复性。气体在蒽环类化疗后预测早期心肌损伤具有更大的价值。

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