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首页> 外文期刊>IUBMB life >Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance
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Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance

机译：C1Q / TNF相关蛋白-3的血清水平炎症性肠病患者及其与炎症细胞因子和胰岛素抵抗的反比关系

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摘要

Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD), which is an inflammatory disease. Studies have shown that adipose tissue and inflammation play important roles in the pathogenesis of IBD. C1q/TNF-related protein-3 (CTRP3) is a newly discovered adipokine playing a substantial role during inflammatory process, and for the first time in the present study, serum levels of this adipokine were measured in the UC and CD patients. This case-control study included 70 control, 50 UC, and 50 CD patients who were diagnosed by standard criteria. Serum levels of adiponectin, IL-6, TNF-alpha, TGF-beta, and CTRP3 were evaluated using ELISA kits. Serum levels of IL-6, TNF-alpha, and TGF-beta elevated in the UC and CD patients compared with the controls while adiponectin and CTRP3 diminished in the patient's groups compared with the control. Furthermore, decrease in CTRP3 serum levels was associated with the risk of UC and CD diseases. Moreover, CTRP3 indicated negative correlation with BMI, FBS, insulin, homeostasis model assessment of insulin resistance, IL-6, TNF-alpha, and TGF-beta and also a positive correlation with adiponectin in both the UC and CD patients. For the first time, the present study demonstrated lower levels of CTRP3 in the UC and CD patients. Decreased serum levels of CTRP3 and its inverse relationship with inflammatory cytokines and TGF-beta levels suggested a possible role for CTRP3 in the pathogenesis of UC and CD diseases.
机译：溃疡性结肠炎（UC）和CrOhn的疾病（CD）是两种主要形式的炎性肠病（IBD），这是一种炎症性疾病。研究表明，脂肪组织和炎症在IBD的发病机制中起重要作用。 C1Q / TNF相关的蛋白-3（CtrP3）是一种新发现的脂肪因子在炎症过程中发挥重要作用，并且在本研究中首次，在UC和CD患者中测量这种己岛的血清水平。这种情况对照研究包括70例对照，50毫升和50名CD患者被标准标准诊断出来。使用ELISA试剂盒评估血清脂肪蛋白，IL-6，TNF-α，TGF-β和CTRP3。与对照组相比，UC和CD患者的IL-6，TNF-α和TGF-β血清IL-6，TNF-α和TGF-β在患者组中与对照组中的脂肪蛋白和CTRP3减少。此外，CTRP3血清水平的降低与UC和CD疾病的风险有关。此外，CTRP3表明与BMI，FBS，胰岛素，胰岛素抵抗，IL-6，TNF-α和TGF-β的稳态模型评估以及与UC和CD患者的脂联素的正相关性的负相关性。本研究首次证明了UC和CD患者中的较低水平的CTRP3。降低CtrP3的血清水平及其与炎性细胞因子和TGF-β水平的反相关系表明CTRP3在UC和CD疾病发病机制中的可能作用。

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