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Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology

机译:肌醇多磷酸激酶在调节核过程和发育生物学中的作用

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摘要

Recent studies have provided many new insights into the regulation and biology of inositide signaling thereby fueling interest in the cellular roles of water-soluble inositol polyphosphate (IP) pathways (Berridge, 1993; Hokin, 1985; Irvine and Schell, 2001; Kapeller and Cantley, 1994; Majerus, 1992; Mikoshiba, 1997; Nishizuka, 1986; Shears, 1998; York, 2006; York et al., 2001). The landmark studies demonstrating that cellular stimuli activate phosphoinositide-specific phospholipase C (PLC) resulting in the production of intracellular messengers inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG) provided the rationale for understanding signaling pathways dependent on water-soluble IP molecules (see reviews, Berridge, 1993; Nishizuka, 1986). Over 20 such IP codes have been identified in cells, most of which are conserved through eukaryotes (see reviews Irvine and Schell, 2001; Majerus, 1992; Shears, 1998).
机译:最近的研究为肌醇信号传导的调控和生物学提供了许多新见解,从而激发了人们对水溶性肌醇多磷酸(IP)途径的细胞作用的兴趣(Berridge,1993; Hokin,1985; Irvine和Schell,2001; Kapeller和Cantley ,1994; Majerus,1992; Mikoshiba,1997; Nishizuka,1986; Shears,1998; York,2006; York等,2001)。具有里程碑意义的研究表明,细胞刺激会激活磷酸肌醇特异性磷脂酶C(PLC),从而导致细胞内信使产生肌醇1,4,5-三磷酸(IP3)和1,2-二酰甘油(DAG),为理解信号通路提供了理论依据取决于水溶性IP分子(参见评论,Berridge,1993; Nishizuka,1986)。在细胞中已经鉴定出20多种这样的IP代码,其中大多数是通过真核生物保存的(请参阅Irvine和Schell,2001; Majerus,1992; Shears,1998)。

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