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Fructosamine 3-kinase and other enzymes involved in protein deglycation

机译：果糖胺3激酶和其他参与蛋白质脱糖的酶

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摘要

It is generally admitted that the only macromolecule that needs to be repaired in cells is DNA. Other macromolecules, and proteins in particular, if damaged, can be destroyed and rebuilt. Contrary to this view, a few protein-repair mechanisms have been identified in cells. One of them, protein deglycation, is the subject of this short review. It should be said at the outset that we are still far from understanding all the implications of this new repair mechanism, though the basic fact, that enzymes able to deglycate proteins exist and function in cells, is now clearly established. As explained at the end of this text, it is likely that many more protein repair mechanisms remain to be identified and some of them may play an important role in the pathophysiology of diseases. The lessons derived from the repair mechanisms that have been identified up to now may help identify these unknown mechanisms.
机译：通常认为，细胞中唯一需要修复的大分子是DNA。其他大分子，尤其是蛋白质，如果遭到破坏，可以被破坏和重建。与这种观点相反，已经在细胞中鉴定了一些蛋白质修复机制。其中之一，蛋白质脱糖，是本篇简短综述的主题。从一开始就应该说，尽管基本事实已经清楚地确定了能够使蛋白质脱糖的酶在细胞中存在并起作用的基本事实，但我们仍然距离了解这种新修复机制的所有含义还很远。正如本文结尾所解释的，可能还有更多的蛋白质修复机制尚待确定，其中一些可能在疾病的病理生理学中起重要作用。到目前为止，已经从修复机制中吸取的教训可能有助于识别这些未知的机制。

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