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首页> 外文期刊>International Journal of Medicinal Mushrooms >Evaluation of Antiarthritic Effect of Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus cv. Florida (Agaricomycetes) on Complete Freund's Adjuvant Induced Arthritis in Rats
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Evaluation of Antiarthritic Effect of Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus cv. Florida (Agaricomycetes) on Complete Freund's Adjuvant Induced Arthritis in Rats

机译：烹饪 - 药用牡蛎蘑菇PLEUROTUS OSTREATES CV的抗炎作用评价。 佛罗里达州（姬松茸）在完全弗氏佐剂诱导的大鼠中的关节炎

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摘要

The present study evaluates the antiarthritic effect of hydroethanolic extract of Pleurotus ostreatus cv. Florida, which was tested against adjuvant induced arthritis in rat models. Arthritis was induced by administration of complete Freund's adjuvant into the subplantar surface of left paw of rats. The extract was given orally at doses 200 mg/ kg and 400 mg/kg and piroxicam was administered intraperitonially (4 mg/kg). In vitro testing on parameters including antiproteinestrase, albumin denaturation and heat induce hemolysis was also carried out. There was significant decrease (p 0.001) in proteinase activity and membrane stabilization in vivo studies on cv. Florida extract treated rats showed a significant (p 0.001) decrease in paw volume, joint diameter, and spontaneous change in body weight recorded for 21 days. The treatment also resulted in an increase in rats' gripping activity compared with arthritic control rats. X-ray examinations showed a decrease in joint swelling. Histopathological examination of the extract treated group showed a significant decrease in joint space. There was also an increase in antibody levels. The antioxidant parameters showed a significant (p 0.001) increase in superoxide dismutase and catalase enzymatic activities. Thus P. ostreatus cv. Florida extract demonstrates a potent antioxidant activity in a rat model. It is concluded that the P. astreatus cv. Florida extract contains medicinally important constituents that show antiarthritic activity in rats.
机译：本研究评估了Pleurotus Ostreatus CV的氢丙基醇提取物的抗炎作用。佛罗里达州（佛罗里达州）在大鼠模型中针对佐剂诱导的关节炎进行了测试。通过将完全弗氏佐剂施用到大鼠左爪子的甲板表面诱导关节炎。将提取物口服给予剂量200mg / kg，400mg / kg和吡嗪腹腔内（4mg / kg）给药。还进行了对包括抗磷酸盐酶，白蛋白变性和热诱导溶血的参数的体外测试。蛋白酶活性和体内CV研究中的蛋白酶活性和膜稳定性显着降低（P <0.001）。佛罗里达州提取物处理的大鼠显示出显着的（P <0.001）减少爪体积，关节直径和在21天记录的体重的自发变化。与关节炎对照大鼠相比，治疗也导致大鼠夹持活性增加。 X射线检查显示联合肿胀的减少。提取物治疗组的组织病理学检查显示有关间隙的显着降低。抗体水平也增加。抗氧化剂参数显示出超氧化物歧化酶和过氧化酶酶活性增加的显着（P <0.001）增加。因此P. Ostreatus CV。佛罗里达州提取物证明了大鼠模型中有效的抗氧化活性。得出结论是，P. AstaTeatus CV。佛罗里达州提取物含有药用的重要成分，在大鼠中显示出抗炎活性。

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