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首页> 外文期刊>International Journal of Medicinal Mushrooms >Anti-Inflammatory and Wound-Healing Potential of Golden Chanterelle Mushroom, Cantharellus cibarius (Agaricomycetes)
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Anti-Inflammatory and Wound-Healing Potential of Golden Chanterelle Mushroom, Cantharellus cibarius (Agaricomycetes)

机译：Golden Chanterelle蘑菇的抗炎和伤口愈合潜力，Cantharellus cibarius（姬松茸）

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摘要

The golden chanterelle mushroom, Cantharellus cibarius, is an edible mushroom with medicinal value. Given that this species has good radical scavenging activity and strong antioxidant potential and bactericidal effects, this study was designed to investigate the anti-inflammatory and wound-healing activity of C. cibarius extract in rats. For this experimental study, circular excision and linear incision wound models were used in 4 groups of male Wistar rats: nontreated, vehicle-treated, treated with C. cibarius extract ointment (2% w/w), and treated with the reference drug (Madecassol). All the animals were treated topically once a day. The circular and linear wounds were treated for 9 and 17 days, respectively. At the end of the study, samples from healing wounds were taken for histopathological assessment to determine the in vivo anti-inflammatory activity and investigate immunohistochemistry by cyclooxygenase-2 (COX-2). Significant wound-healing activity in each wound model was observed in the C. cibarius extract-treated and Madecassol-treated groups compared with the nontreated and vehicle-treated groups (P 0.05). Histological assessment showed complete repair of the epidermal layer, increased collagen production, and a remarkable degree of neovascularization and epithelization in the extract group, which were significantly different from those in the other groups (P 0.05). In addition, a significantly lower rate of COX-2 expression was detected in the extract group than in the nontreated and vehicle-treated groups (P 0.0001). Therefore, the experimental data reveal that C. cibarius extract showed significant wound-healing and anti-inflammatory effects, which could be the scientific rationale for the medicinal use of the golden chanterelle mushroom in treating wounds.
机译：Golden Chanterelle蘑菇，Cibarus Cibarius是一种具有药物价值的食用蘑菇。鉴于该物种具有良好的激进清除活性和强烈的抗氧化潜力和杀菌效果，设计了研究大鼠C.Cibarius提取物的抗炎和伤口愈合活性。对于该实验研究，圆形切除和线性切口缠绕模型用于4组雄性Wistar大鼠：用C. cibarius提取软膏（2％w / w）处理，并用参考药物处理（ Madecassol）。所有的动物每天局部地治疗一次。圆形和线性伤口分别处理9和17天。在研究结束时，采用来自愈合伤口的样品进行组织病理学评估，以确定体内抗炎活性，并通过环氧氧酶-2（COX-2）研究免疫组织化学。与非处理和载体处理的基团相比，在C.Cibarius提取物处理和MADecassol处理基团中观察到每个伤口模型中的显着伤口愈合活性。（P <0.05）。组织学评估显示表皮层的完全修复，胶原蛋白产量增加，以及提取物组中的显着性新血管形成和上皮，其与其他基团中的那些显着不同（P <0.05）。此外，在提取物组中检测到比在非处理和载体处理基团中的显着较低的COX-2表达速率（P <0.0001）。因此，实验数据揭示了C.Cibarius提取物显示出显着的伤口愈合和抗炎作用，这可能是金黄菌蘑菇在治疗伤口时使用的科学原理。

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