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首页> 外文期刊>BJU international >Paradoxical expression of E-cadherin in prostatic bone metastases.
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Paradoxical expression of E-cadherin in prostatic bone metastases.

机译：E-钙黏着蛋白在前列腺骨转移中的反常表达。

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OBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION: E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
机译：目的：确定钙依赖性细胞粘附分子E-钙黏着蛋白是否在骨的前列腺癌转移沉积物中表达。患者和方法：获得十份含有未经治疗的前列腺癌转移性沉积物的骨活检，并使用链霉亲和素-生物素复合物技术用单克隆抗体HECD-1对E-钙黏着蛋白进行免疫组织化学染色。良性前列腺组织用作对照。结果：在10个标本中，有9个显示出E-钙粘蛋白的阳性表达，其中有4个被评为强。 E-钙黏着蛋白表达在分化良好的转移灶中最强，并随着肿瘤等级的增加而降低。在一些标本中，有多种表达方式。结论：E-钙黏着蛋白在前列腺骨转移中强烈表达，表达程度似乎反映了局部肿瘤的分级。这表明E-钙粘蛋白表达的丧失可能与转移潜能没有关键联系。

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