...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EMBO reports >The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1
【24h】

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1

机译：突变体P53-ID4复合物通过募集LNCRNA MALAT1对VEGFA同种型进行控制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been associated with a poorly differentiated and aggressive phenotype of mammary carcinomas. This long non-coding RNA (lncRNA) localizes to nuclear speckles, where it interacts with a subset of splicing factors and modulates their activity. In this study, we demonstrate that oncogenic splicing factor SRSF1 bridges MALAT1 to mutant p53 and ID4 proteins in breast cancer cells. Mutant p53 and ID4 delocalize MALAT1 from nuclear speckles and favor its association with chromatin. This enables aberrant recruitment of MALAT1 on VEGFA pre-mRNA and modulation of VEGFA isoforms expression. Interestingly, VEGFA-dependent expression signatures associate with ID4 expression specifically in basal-like breast cancers carrying TP53 mutations. Our results highlight a key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins.
机译：丰富，核保留的转移相关肺腺癌转录物1（Malat1）与乳腺癌的差异和激进表型有关。 这种长的非编码RNA（LNCRNA）定位于核斑点，其与剪接因子的子集相互作用并调节其活动。 在这项研究中，我们证明致癌剪接因子SRSF1桥接到乳腺癌细胞中的MALAT1至突变体P53和ID4蛋白。 突变体P53和ID4将Malat1从核斑点删除，并赞成其与染色质的关系。 这使得Malat1在VEGFA前mRNA上的异常募集和VEGFA同种型表达的调节。 有趣的是，VEGFA依赖表达签名与ID4表达有关，具体在携带TP53突变的基底乳腺癌中。 我们的结果突出了MALAT1在表达函数突变体P53和ID4蛋白的乳腺癌细胞中对VEGFA同种型表达的控制中的关键作用。

著录项

  • 来源
    《EMBO reports》 |2017年第8期|共21页
  • 作者

    Pruszko Magdalena; Milano Elisa; Forcato Mattia; Donzelli Sara; Ganci Federica; Di Agostino Silvia; De Panfilis Simone; Fazi Francesco; Bates David O.; Bicciato Silvio; Zylicz Maciej; Zylicz Alicja; Blandino Giovanni; Fontemaggi Giulia;

  • 作者单位

    Int Inst Mol &

    Cell Biol Warsaw Dept Mol Biol Warsaw Poland;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

    Univ Modena &

    Reggio Emilia Dept Life Sci Ctr Genome Res Modena Italy;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

    Ist Italiano Tecnol Ctr Life Nano Sci Rome Italy;

    Sapienza Univ Rome Dept Anat Histol Forens &

    Orthoped Sci Sect Histol &

    Med Embryol Rome Italy;

    Univ Nottingham Div Canc &

    Stem Cells Canc Biol Sch Med Queens Med Ctr Nottingham England;

    Univ Modena &

    Reggio Emilia Dept Life Sci Ctr Genome Res Modena Italy;

    Int Inst Mol &

    Cell Biol Warsaw Dept Mol Biol Warsaw Poland;

    Int Inst Mol &

    Cell Biol Warsaw Dept Mol Biol Warsaw Poland;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

    Italian Natl Canc Inst Regina Elena Oncogen &

    Epigenet Unit Rome Italy;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

    ID4; MALAT1; mutant p53; SRSF1; VEGFA;

    机译：ID4;malat1;突变体p53;srsf1;VEGFA;

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号