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首页> 外文期刊>Endocrine. >Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, open-label, crossover pilot study
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Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, open-label, crossover pilot study

机译：在用餐前30分钟服用二甲双胍而不是用膳食服用二甲双胍来改善餐后高血糖。 随机开放标签，交叉试点研究

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摘要

Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism. As an animal model, 18 Zucker-rats were divided into three groups as follows: no medication (Control), metformin (600 mg/kg) with meal (Met), and metformin 10 min before meal (pre-Met). In addition, five diabetic patients were recruited and randomized to take metformin (1000 mg) either 30 min before a meal (pre-Met protocol) or with a meal (Met protocol). In the animal model, the peak glucose level of pre-Met (7.8 +/- A 1.5 mmol/L) was lower than that of Control (12.6 +/- A 2.5 mmol/L, P = 0.010) or Met (14.1 +/- A 2.9 mmol/L, P = 0.020). Although there was no statistical difference among the three groups, total GLP-1 level at t = 0 min of pre-Met (7.4 +/- A 2.7 pmol/L) tended to be higher than that of Control (3.7 +/- A 2.0 pmol/L, P = 0.030) or Met (3.9 +/- A 1.2 pmol/L, P = 0.020). In diabetic patients, the peak glucose level of pre-Met protocol (7.0 +/- A 0.4 mmol/L) was lower than that of Met protocol (8.5 +/- A 0.9 mmol/L, P = 0.021). Total GLP-1 level at t = 30 min of pre-Met protocol (11.0 +/- A 6.1 pmol/L) was higher than that of Met protocol (6.7 +/- A 3.9 pmol/L, P = 0.033). Taking metformin 30 min before a meal ameliorated postprandial hyperglycemia. This promises to be a novel approach for postprandial hyperglycemia.
机译：已经显示用膳食服用二甲双胍来降低二甲双胍的生物利用度。我们假设在膳食提高葡萄糖代谢前30分钟服用二甲双胍。作为一种动物模型，将18只Zucker-大鼠分为三组，如下：没有用餐（对照），二甲双胍（600mg / kg），饭前10分钟（在达到）前10分钟此外，招募了五名糖尿病患者并随机服用于膳食前30分钟的二甲双胍（1000mg）或用餐（符合协议）。在动物模型中，预先满足的峰葡萄糖水平低于对照（12.6 +/- 2.5mmol / L，P = 0.010）或满足（14.1 + / - 2.9 mmol / L，p = 0.020）。虽然三组中没有统计学差异，但是在遇到的预见（7.4 +/- a 2.7 pmol / l）的t = 0 min的GLP-1水平趋于高于对照（3.7 +/- a） 2.0 pmol / l，p = 0.030）或满足（3.9 +/- 1.2 pmol / l，p = 0.020）。在糖尿病患者中，Met Prease（7.0 +/- 0.4mmol / L）的峰葡萄糖水平低于MET方案（8.5 +/- 0.9mmol / L，P = 0.021）。在Met Pre-Met协议（11.0 +/- 6.1 pmol / L）的T = 30分钟的GLP-1水平高于MET协议（6.7 +/- 3.9 pmol / L，P = 0.033）。在膳食后30分钟服用二甲双胍在后期高血糖症。这承诺成为后催化高血糖的新方法。

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  • 来源
    《Endocrine.》 |2016年第2期|共6页
  • 作者

    Hashimoto Yoshitaka; Tanaka Muhei; Okada Hiroshi; Mistuhashi Kazuteru; Kimura Toshihiro; Kitagawa Noriyuki; Fukuda Takuya; Majima Saori; Fukuda Yukiko; Tanaka Yoshimitsu; Yamada Shunji; Senmaru Takafumi; Hamaguchi Masahide; Asano Mai; Yamazaki Masahiro; Oda Yohei; Hasegawa Goji; Nakamura Naoto; Fukui Michiaki;

  • 作者单位

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Japanese Red Cross Kyoto Daini Hosp Div Metab Nephrol &

    Rheumatol Kyoto Japan;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Anat &

    Neurobiol Kyoto Japan;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Japanese Red Cross Kyoto Daini Hosp Div Metab Nephrol &

    Rheumatol Kyoto Japan;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

    Kyoto Prefectural Univ Med Dept Endocrinol &

    Metab Grad Sch Med Sci Kamigyo Ku 465 Kajii Cho;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
  • 关键词

    Postprandial hyperglycemia; Metformin; Biguanides; Type 2 diabetes; Glucagon-like peptide-1 (GLP-1); Incretin; Gastric emptying;

    机译：后催化高血糖;二甲双胍;双胍;2型糖尿病;胰高血糖素肽-1（GLP-1）;Incetin;胃排空;

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