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The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia

机译:肝细胞和免疫细胞之间的复杂相互作用在炎症和高血糖血症中胆固醇代谢之间的十字路口

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摘要

An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.
机译:2型糖尿病炎症故事的有趣证据表明了光明。 最近的okin和同事的研究为胆固醇代谢和免疫之间的相互作用增加了新的线索以及它如何影响葡萄糖稳态在炎症条件下。 但有些问题是仍未解决的难题。 在这里,我们建议更好地解剖甲羟戊酯途径的调节机制,并在免疫素失调和糖尿病之间支撑新的致病联系。

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