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首页> 外文期刊>Electroanalysis >Carbon Nanotubes Modified Graphite Electrodes for Monitoring of Biointeraction Between 6-Thioguanine and DNA
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Carbon Nanotubes Modified Graphite Electrodes for Monitoring of Biointeraction Between 6-Thioguanine and DNA

机译：碳纳米管改性石墨电极，用于监测6-Thioguanine和DNA之间的生物互连

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In this present study, single-walled carbon nanotubes (SWCNT) modified disposable pencil graphite electrodes (SWCNT-PGEs) were developed for the electrochemical monitoring of anticancer drug, and its interaction with double stranded DNA (dsDNA). Under this aim, SWCNT-PGEs were applied for the first time in the literature to analyse of 6-Thioguanine (6-TG), and also to investigate its interaction with DNA by voltammetric and impedimetric methods. The surface morphologies of PGE and SWCNT-PGE were explored using scanning electron microscopy (SEM) and electrochemical characterization of unmodified/modified electrodes was performed by cyclic voltammetry (CV). Experimental parameters; such as, the concentration of 6-TG and its interaction time with dsDNA were optimized by using differential pulse voltammetry (DPV). Additionally, the interaction of 6-TG with dsDNA was studied in case of different interaction times by electrochemical impedance spectroscopy (EIS) in contrast to voltammetric results. The detection limit of 6-TG was found to be 0.25 mu M by SWCNT-PGE.
机译：在本研究中，为抗癌药物的电化学监测开发了单壁碳纳米管（SWCNT）改性一次性铅笔石墨电极（SWCNT-PGES），其与双链DNA（DSDNA）的相互作用。在此目的下，在文献中首次应用SWCNT钢琴以分析6-Thioguanine（6-Tg），并通过伏安和阻抗方法研究其与DNA的相互作用。使用扫描电子显微镜（SEM）探索PGE和SWCNT-PGE的表面形态，并通过循环伏安法（CV）进行未修饰/改性电极的电化学表征。实验参数;如，通过使用差分脉冲伏安法（DPV）优化了6-Tg的浓度及其与DSDNA的相互作用时间。另外，在电化学阻抗光谱（EIS）与伏安效果相比，在不同的相互作用时间的情况下，研究了6-Tg与DSDNA的相互作用。发现6-Tg的检出限为SWCNT-PGE为0.25μm。

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