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Centri-Voltammetric Folic Acid Detection

机译：Centri-伏安叶酸检测

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The need for practical detection of folic acid (FA) has been increased day by day. For this reason in this work, a two steps electroanalytical technique, centri-voltammetry was utilized for FA detection for the first time. In order to get rid of the slow electrode kinetics of FA oxidation, the working electrode was modified with graphene-Pt hibrid nanomaterial. Also for increasing the sensitivity, 1-Chloro-2-[2-(2-methoxyethoxy) ethoxy]ethane (TEG-Cl) and 1,2-di{2-[2-(2-methoxyethoxy)ethoxy] ethoxy}-4-nitrobenzene (4NC-NO2) was used as a carrier material. After the characterization of graphene-Pt hybrid nanomaterial, experimental parameters like, 4NC-NO2 amount, adsorption time, centri-voltammetric parameters like centrifuge time and speed were optimized. After that, analytical characteristics such as linear range, relative standard deviation (R.S.D), limit of detection (LOD) and limit of quantification (LOQ) values were found. In this manner, linear range was obtained for FA between 1.0 mu M-1000 mu M with the equations of y=0.0108x+1.0459 (R-2=0.9977). R.S.D value was calculated for 0.83 mM FA (n=3) as 1.86 % while LOD and LOQ values were found as 1.00 mu M and 3.34 mu M respectively. After the examination of interference effect of substances like ascorbic acid and uric acid, established centri-voltammetric technique was enforced for FA detection in pharmateutical tablets. As a result, the recovery value was calculated as 96.4 %.
机译：对叶酸（FA）进行实际检测的需求日益增长。因此，在这项工作中，电催化技术的两个步骤，即将到第一次用于FA检测的Centri-Voltametry。为了摆脱FA氧化的慢电极动力学，用石墨烯-PT螺柱纳米材料改性工作电极。还用于增加敏感性，1-氯-2- [2-（2-甲氧基乙氧基）乙氧基]乙烷（TEG-CL）和1,2-DI {2- [2-（2-甲氧基乙氧基）乙氧基]乙氧基} - 使用4-硝基苯（4NC-NO2）作为载体材料。在石墨烯-PT杂交纳米材料的表征后，实验参数如，4NC-NO2量，吸附时间，优化了离心时间和速度等离心参数。之后，找到了线性范围，相对标准偏差（R.S.D），检测极限（LOD）和定量限制（LOQ）值的分析特性。以这种方式，在1.0μm-1000μm之间获得线性范围，y = 0.0108x + 1.0459的等式（R-2 = 0.9977）。 R.S.D值计算为0.83 mm fa（n = 3），为1.86％，而LOD和LOQ值分别为1.00 mu m和3.34 mu m。在抗坏血酸和尿酸等物质的干扰效果检查后，在药房药片中强制进行建立的Centri-Voldametric技术。结果，将回收值计算为96.4％。

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