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Iron(III)-mediated Electrochemical Detection of Levofloxacin in Complex Biological Samples

机译：铁（III）型电化学检测左旋氧氟辛嘧啶在复杂的生物样品中

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摘要

We report the design of an electrochemical sensor capable of detecting levofloxacin (LEVX) in complex biological samples. This detection strategy is simple, fast, and does not require sample pretreatment or electrode modification. Unlike previously developed electrochemical LEVX sensors that require direct oxidation of LEVX, the sensing mechanism is based on the complexation reactions between LEVX and iron(III), resulting in a concentration-dependent decrease in the iron(III) reduction peak current and a shift in the peak potential. These changes are presumably attributed to the decrease in the concentration of uncomplexed Fe(III) in the solution. The concentration-dependent change in both the current and potential can be used for quantification of LEVX in various samples, including 50% synthetic urine and 25% synthetic human saliva. The limit of detection was estimated to be in the range of 1.5 to 2.3 mu M, concentrations that are much lower than the concentration of LEVX found in urine and saliva samples of patients administered this drug for conditions such as urinary tract infection. With further optimization, this sensing strategy could find applications in clinical pharmacokinetic studies.
机译：我们报道了一种能够在复杂的生物样品中检测左氧氟沙星（Levx）的电化学传感器的设计。这种检测策略简单，快速，并且不需要样品预处理或电极改性。与先前开发的电化学Levx传感器不同，需要直接氧化Levx，传感机制基于Levx和铁（III）之间的络合反应，从而导致铁（III）的浓度依赖性降低，减少峰值电流和移位峰值潜力。这些变化可能归因于溶液中未复合Fe（III）的浓度降低。电流和潜力的浓度依赖性变化可用于各种样品中Levx的定量，包括50％的合成尿和25％合成人类唾液。估计检测限估计为1.5至2.3μm，浓度低于尿液中发现的尿液和唾液样品的血迹浓度的浓度用于尿路感染如尿路感染的条件下给药。通过进一步优化，这种感测策略可以在临床药代动力学研究中找到应用。

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