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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Apathy in rapid eye movement sleep behaviour disorder is common and under‐recognized
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Apathy in rapid eye movement sleep behaviour disorder is common and under‐recognized

机译：快速眼球运动的冷漠睡眠行为障碍是普遍的，不公认的

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Background and purpose Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder ( RBD ) have a high probability of developing PD in future. Neuropsychiatric problems are common in RBD , but apathy has not previously been detailed in this key prodromal population. Methods Eighty‐eight patients with polysomnographically proven RBD , 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale. Cognition and depression were also quantified. The sensitivity of the Unified Parkinson's Disease Rating Scale screening questions for apathy and depression was calculated. Results A total of 46% of patients with RBD were apathetic, compared with 31% of patients with PD in our sample. Most patients with RBD with depression were apathetic but more than half of apathetic patients were not depressed. The sensitivity of the single Unified Parkinson's Disease Rating Scale screening question was only 33% for mild apathy and 50% for severe apathy. Conclusions Apathy is common in RBD and is underestimated by a single self‐report question. Recognition of apathy as a distinct neuropsychiatric feature in RBD could aid targeted treatment interventions and might contribute to the understanding of prodromal PD.
机译：背景和目的冷漠是帕金森病（PD）的重要神经精神特征，经常在运动症状发作之前出现。快速眼睛运动睡眠行为障碍（RBD）患者未来具有高概率开发PD。神经精神问题在RBD中是常见的，但此前没有在这种关键的前驱群体中进行过冷漠。方法使用Lille Apathy评级规模评估八十八条患有PD验证RBD，65例PD和33例对照的患者。还量化了认知和抑郁症。计算了统一帕金森病评级规模筛选症状和抑郁症的敏感性。结果46％的RBD患者持催害，而我们样本中有31％的患者。大多数患有抑郁症患者的患者持催眠，但一半以上的冷漠患者没有抑郁。单一统一帕金森病评级规模筛查问题的敏感性仅为轻度冷漠的33％，严重脾气暴躁40％。结论脾气暴躁是狂热的常见问题，并被单一的自我报告问题低估。作为RBD中的明显神经精神特征的疾病识别可以帮助靶向治疗干预，并可能有助于了解前驱PD。

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